PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product name	CAS No.	Purity
T4219	Autophinib	1644443-47-9	98.83%
T4219	Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamy...
T2256	CNX-1351	1276105-89-5	98.83%
T2256	CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
T67704	MTOR inhibitor 9e	1144075-40-0	98.80%
T67704	mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.
T6072	BGT226 maleate	1245537-68-1	98.78%
T6072	BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .
TN1459	Bufarenogin	17008-65-0	98.77%
TN1459	Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad P...
T67706	MTOR inhibitor 9c	1144075-36-4	98.73%
T67706	mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.
T5736	1,3-Dicaffeoylquinic acid	19870-46-3	98.68%
T5736	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
T16841	SAR-260301	1260612-13-2	98.65%
T16841	SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).
T6251	PF-04691502	1013101-36-4	98.63%
T6251	PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
T6774	AZD-8835	1620576-64-8	98.49%
T6774	AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).
T1879	3-Methyladenine	5142-23-4	98.44%
T1879	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autop...
T7944	VPS34 inhibitor 1 (Compound 19, PIK-III analogue)	1383716-46-8	98.44%
T7944	VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)
T26252	PI3Kδ-IN-3	1431540-99-6	98.43%
T26252	PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.
T6103	VS-5584	1246560-33-7	98.41%
T6103	VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.
TN2063	Physalin B	23133-56-4	98.40%
TN2063	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
T1827	Buparlisib	944396-07-0	98.4%
T1827	Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).
T67701	MTOR inhibitor 9f	1144075-42-2	98.39%
T67701	mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.
TN1819	Kaempferol 3-neohesperidoside	32602-81-6	98.34%
TN1819	Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, demonstrates an insulinomimetic effect on the rat soleus muscle.
T3780	Oroxin B	114482-86-9	98.33%
T3780	Oroxin B (Hypocretin-2) has antioxidant activity.
T6731	WYE-354	1062169-56-5	98.31%
T6731	WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selec...