Home Tools
Log in
Cart

PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3208 Brevianamide F 38136-70-8 97.30%
Brevianamide F
Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess i...
T1826 PI3K-IN-1 1349796-36-6 97.07%
PI3K-IN-1
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T7015 Vps34-IN-1 1383716-33-3 97.04%
Vps34-IN-1
Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I...
T6630 Quercetin Dihydrate 6151-25-3 97.03%
Quercetin Dihydrate
Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine...
T3190 PIK-inhibitors 371934-59-7 96.98%
PIK-inhibitors
PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.
TN1153 Polyporenic acid C 465-18-9 96.84%
Polyporenic acid C
Polyporenic acid C shows inhibitory activity against human collagenase.
TN1405 Arnicolide D 34532-68-8 96.66%
Arnicolide D
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T11593 I-OMe-Tyrphostin AG 538 1094048-77-7 96.66%
I-OMe-Tyrphostin AG 538
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated sig...
T6817 Deguelin 522-17-8 96.39%
Deguelin
Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
T6072L BGT226 915020-55-2 95.74%
BGT226
BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
T13140 Umbralisib R-enantiomer 1532533-69-9 95.61%
Umbralisib R-enantiomer
Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against...
T2836 Isorhamnetin 480-19-3 92.82%
Isorhamnetin
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorh...
T3541 CC-115 1228013-15-7 86.79%
CC-115
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
T4199 Desmethyl-VS-5584 1246535-95-4 100%
Desmethyl-VS-5584
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
T1056 Isoprenaline hydrochloride 51-30-9 100%
Isoprenaline hydrochloride
Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
T2660 IC-87114 371242-69-2 100%
IC-87114
IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).
T14511 BAY1082439 1375469-38-7 100%
BAY1082439
BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2] and it is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 a...
T3656 PKI-402 1173204-81-3 100%
PKI-402
PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.
T2433 NU 7026 154447-35-5 100%
NU 7026
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition aga...
T7879 TASP0415914 1292300-75-4 100%
TASP0415914
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
Brevianamide F
T3208
Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess i...
PI3K-IN-1
T1826
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
Vps34-IN-1
T7015
Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I...
Quercetin Dihydrate
T6630
Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine...
PIK-inhibitors
T3190
PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.
Polyporenic acid C
TN1153
Polyporenic acid C shows inhibitory activity against human collagenase.
Arnicolide D
TN1405
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
I-OMe-Tyrphostin AG 538
T11593
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated sig...
Deguelin
T6817
Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
BGT226
T6072L
BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
Umbralisib R-enantiomer
T13140
Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against...
Isorhamnetin
T2836
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorh...
CC-115
T3541
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
Desmethyl-VS-5584
T4199
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
Isoprenaline hydrochloride
T1056
Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
IC-87114
T2660
IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).
BAY1082439
T14511
BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2] and it is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 a...
PKI-402
T3656
PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.
NU 7026
T2433
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition aga...
TASP0415914
T7879
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
TargetMol