T2616 |
PIK-93
|
593960-11-3
|
99.83%
|
|
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
|
T4976 |
Umbralisib
|
1532533-67-7
|
99.83%
|
|
Umbralisib (TGR 1202) is a PI3Kδ inhibitor.
|
T3675 |
1-Deoxynojirimycin
|
19130-96-2
|
99.82%
|
|
1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
|
TQ0044 |
Seletalisib
|
1362850-20-1
|
99.81%
|
|
Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).
|
T2685 |
KU-55933
|
587871-26-9
|
99.80%
|
|
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
|
T3348 |
PIK-293
|
900185-01-5
|
99.8%
|
|
PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.
|
T3985 |
GDC-0326
|
1282514-88-8
|
99.79%
|
|
GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).
|
T16567 |
PQR530
|
1927857-61-1
|
99.78%
|
|
PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphor...
|
T15592 |
IPI-3063
|
1425043-73-7
|
99.77%
|
|
IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
|
T9460 |
IMDK
|
881970-80-5
|
99.77%
|
|
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits no...
|
T2008 |
LY294002
|
154447-36-6
|
99.76%
|
|
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC...
|
T2798 |
Esculetin
|
305-01-1
|
99.76%
|
|
Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema,...
|
T6433 |
CAY10505
|
1218777-13-9
|
99.74%
|
|
CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).
|
T61618 |
PI3K-IN-38
|
1382979-64-7
|
99.74%
|
|
PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 µM for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activ...
|
T13119 |
Tenalisib
|
1639417-53-0
|
99.71%
|
|
Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)
|
T2235 |
Dactolisib
|
915019-65-7
|
99.71%
|
|
Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
|
T3533 |
Apilimod mesylate
|
870087-36-8
|
99.7%
|
|
Apilimod mesylate (STA 5326 mesylate) is a potent IL-12/IL-23 inhibitor.
|
T1994 |
Pictilisib
|
957054-30-7
|
99.69%
|
|
Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).
|
T11381 |
Pictilisib dimethanesulfonate
|
957054-33-0
|
99.69%
|
|
Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p1...
|
T60196 |
IHMT-PI3Kδ-372 S-isomer
|
2429889-61-0
|
99.68%
|
|
IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks ...
|