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PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2377 Pilaralisib analogue 956958-53-5 99.46%
Pilaralisib analogue
Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T1999 Taselisib 1282512-48-4 99.46%
Taselisib
Taselisib (GDC-0032) is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplasti...
T21992 Vacuolin-1 351986-85-1 99.45%
Vacuolin-1
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐...
T1949 CZC24832 1159824-67-5 99.45%
CZC24832
CZC24832 is a selective inhibitor of PI 3-kinase γ.
T1988 Duvelisib 1201438-56-3 99.45%
Duvelisib
Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase ...
T13376 YS-49 132836-42-1 99.42%
YS-49
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
T6845 GNE-317 1394076-92-6 99.42%
GNE-317
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
T3351 Onatasertib 1228013-30-6 99.41%
Onatasertib
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
T28416 PIK-108 901398-68-3 99.4%
PIK-108
PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
T6030 XL388 1251156-08-7 99.39%
XL388
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
T8651 CAL-101 1146702-54-6 99.39%
CAL-101
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110...
T16528 PI-828 942289-87-4 99.39%
PI-828
PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differen...
T2018 Apilimod 541550-19-0 99.38%
Apilimod
Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
T6045 Torin 1 1222998-36-8 99.38%
Torin 1
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
T7014 Voxtalisib 934493-76-2 99.36%
Voxtalisib
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
T3P2904 α-Linolenic acid 463-40-1 99.36%
α-Linolenic acid
α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils an...
T1838 Sapanisertib 1224844-38-5 99.34%
Sapanisertib
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antine...
T2418 A66 1166227-08-2 99.33%
A66
A66 is a specific and effective p110α inhibitor(IC50=32 nM).
T2746 Sophocarpine monohydrate 145572-44-7 99.33%
Sophocarpine monohydrate
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T24873 TGX-115 351071-62-0 99.31%
TGX-115
TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regul...
Pilaralisib analogue
T2377
Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
Taselisib
T1999
Taselisib (GDC-0032) is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplasti...
Vacuolin-1
T21992
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐...
CZC24832
T1949
CZC24832 is a selective inhibitor of PI 3-kinase γ.
Duvelisib
T1988
Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase ...
YS-49
T13376
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
GNE-317
T6845
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
Onatasertib
T3351
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
PIK-108
T28416
PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
XL388
T6030
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
CAL-101
T8651
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110...
PI-828
T16528
PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differen...
Apilimod
T2018
Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
Torin 1
T6045
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
Voxtalisib
T7014
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
α-Linolenic acid
T3P2904
α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils an...
Sapanisertib
T1838
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antine...
A66
T2418
A66 is a specific and effective p110α inhibitor(IC50=32 nM).
Sophocarpine monohydrate
T2746
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
TGX-115
T24873
TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regul...
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TargetMol