T2377 |
Pilaralisib analogue
|
956958-53-5
|
99.46%
|
|
Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
|
T1999 |
Taselisib
|
1282512-48-4
|
99.46%
|
|
Taselisib (GDC-0032) is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplasti...
|
T21992 |
Vacuolin-1
|
351986-85-1
|
99.45%
|
|
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐...
|
T1949 |
CZC24832
|
1159824-67-5
|
99.45%
|
|
CZC24832 is a selective inhibitor of PI 3-kinase γ.
|
T1988 |
Duvelisib
|
1201438-56-3
|
99.45%
|
|
Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase ...
|
T13376 |
YS-49
|
132836-42-1
|
99.42%
|
|
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
|
T6845 |
GNE-317
|
1394076-92-6
|
99.42%
|
|
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
|
T3351 |
Onatasertib
|
1228013-30-6
|
99.41%
|
|
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
|
T28416 |
PIK-108
|
901398-68-3
|
99.4%
|
|
PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
|
T6030 |
XL388
|
1251156-08-7
|
99.39%
|
|
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
|
T8651 |
CAL-101
|
1146702-54-6
|
99.39%
|
|
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110...
|
T16528 |
PI-828
|
942289-87-4
|
99.39%
|
|
PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differen...
|
T2018 |
Apilimod
|
541550-19-0
|
99.38%
|
|
Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
|
T6045 |
Torin 1
|
1222998-36-8
|
99.38%
|
|
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
|
T7014 |
Voxtalisib
|
934493-76-2
|
99.36%
|
|
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
|
T3P2904 |
α-Linolenic acid
|
463-40-1
|
99.36%
|
|
α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils an...
|
T1838 |
Sapanisertib
|
1224844-38-5
|
99.34%
|
|
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antine...
|
T2418 |
A66
|
1166227-08-2
|
99.33%
|
|
A66 is a specific and effective p110α inhibitor(IC50=32 nM).
|
T2746 |
Sophocarpine monohydrate
|
145572-44-7
|
99.33%
|
|
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
|
T24873 |
TGX-115
|
351071-62-0
|
99.31%
|
|
TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regul...
|