T4S1335 |
Daphnoretin
|
2034-69-7
|
98%
|
|
1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma...
|
T5600 |
Darovasertib
|
1874276-76-2
|
98%
|
|
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively)...
|
T72322 |
R 59-022 hydrochloride
|
93076-98-3
|
97.7%
|
|
R 59-022 hydrochloride is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits ...
|
T5S2017 |
Ingenol
|
30220-46-3
|
97.53%
|
|
1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develo...
|
T10888 |
CRT0066854 hydrochloride
|
2250019-91-9
|
97.51%
|
|
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
|
T3375 |
Verbascoside
|
61276-17-3
|
97.46%
|
|
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
|
T7604 |
Valrubicin
|
56124-62-0
|
97.41%
|
|
Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
|
T3S1416 |
Decursin
|
5928-25-6
|
97.22%
|
|
1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , ...
|
T6515 |
Go6976
|
136194-77-9
|
95.89%
|
|
Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various ...
|
TN4114 |
Gardenin A
|
21187-73-5
|
95.15%
|
|
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
|
TP1955L |
PKC β pseudosubstrate acetate
|
|
95.01%
|
|
PKC β pseudosubstrate acetate is a selective cell-permeable inhibitor of PKC.
|
TP1924L1 |
ZIP acetate(863987-12-6 free base)
|
TP1924L1
|
94.68%
|
|
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectiv...
|
T6167 |
SU9516
|
377090-84-1
|
92.42%
|
|
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
|
T7885 |
Afuresertib hydrochloride
|
1047645-82-8
|
100%
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
|
T8376 |
PKCβ inhibitor 1
|
257879-35-9
|
100%
|
|
PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).
|
T4391 |
Syk Inhibitor II dihydrochloride
|
227449-73-2
|
100%
|
|
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...
|
TP1789L |
Malantide acetate(86555-35-3 free base)
|
TP1789L
|
100%
|
|
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide tha...
|
TP1053L |
Protein Kinase C 19-31 acetate
|
TP1053L
|
100%
|
|
Protein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with ...
|
T16791 |
Rottlerin
|
82-08-6
|
|
|
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-...
|
T4037 |
Phorbol
|
17673-25-5
|
|
|
Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.
|