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PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4S1335 Daphnoretin 2034-69-7 98%
Daphnoretin
1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma...
T5600 Darovasertib 1874276-76-2 98%
Darovasertib
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively)...
T72322 R 59-022 hydrochloride 93076-98-3 97.7%
R 59-022 hydrochloride
R 59-022 hydrochloride is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits ...
T5S2017 Ingenol 30220-46-3 97.53%
Ingenol
1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develo...
T10888 CRT0066854 hydrochloride 2250019-91-9 97.51%
CRT0066854 hydrochloride
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
T3375 Verbascoside 61276-17-3 97.46%
Verbascoside
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T7604 Valrubicin 56124-62-0 97.41%
Valrubicin
Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
T3S1416 Decursin 5928-25-6 97.22%
Decursin
1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , ...
T6515 Go6976 136194-77-9 95.89%
Go6976
Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various ...
TN4114 Gardenin A 21187-73-5 95.15%
Gardenin A
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
TP1955L PKC β pseudosubstrate acetate 95.01%
PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate is a selective cell-permeable inhibitor of PKC.
TP1924L1 ZIP acetate(863987-12-6 free base) TP1924L1 94.68%
ZIP acetate(863987-12-6 free base)
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectiv...
T6167 SU9516 377090-84-1 92.42%
SU9516
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
T7885 Afuresertib hydrochloride 1047645-82-8 100%
Afuresertib hydrochloride
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T8376 PKCβ inhibitor 1 257879-35-9 100%
PKCβ inhibitor 1
PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).
T4391 Syk Inhibitor II dihydrochloride 227449-73-2 100%
Syk Inhibitor II dihydrochloride
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...
TP1789L Malantide acetate(86555-35-3 free base) TP1789L 100%
Malantide acetate(86555-35-3 free base)
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide tha...
TP1053L Protein Kinase C 19-31 acetate TP1053L 100%
Protein Kinase C 19-31 acetate
Protein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with ...
T16791 Rottlerin 82-08-6
Rottlerin
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-...
T4037 Phorbol 17673-25-5
Phorbol
Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.
Daphnoretin
T4S1335
1. Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma...
Darovasertib
T5600
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively)...
R 59-022 hydrochloride
T72322
R 59-022 hydrochloride is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits ...
Ingenol
T5S2017
1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develo...
CRT0066854 hydrochloride
T10888
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
Verbascoside
T3375
Verbascoside is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
Valrubicin
T7604
Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.
Decursin
T3S1416
1. Decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , ...
Go6976
T6515
Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various ...
Gardenin A
TN4114
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
PKC β pseudosubstrate acetate
TP1955L
PKC β pseudosubstrate acetate is a selective cell-permeable inhibitor of PKC.
ZIP acetate(863987-12-6 free base)
TP1924L1
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectiv...
SU9516
T6167
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
Afuresertib hydrochloride
T7885
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
PKCβ inhibitor 1
T8376
PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).
Syk Inhibitor II dihydrochloride
T4391
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...
Malantide acetate(86555-35-3 free base)
TP1789L
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide tha...
Protein Kinase C 19-31 acetate
TP1053L
Protein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with ...
Rottlerin
T16791
Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-...
Phorbol
T4037
Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.
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TargetMol