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Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T35528 TD52 1798328-24-1 99.5%
TD52
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
T24073 PTP1B-IN-4 765317-72-4 98.19%
PTP1B-IN-4
PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
T3827 Rhein-8-glucoside calcium 113443-70-2
Rhein-8-glucoside calcium
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt) shows moderate bioactivity against human Protein Tyrosine Phosp...
T78217 (R)-Azasetron besylate 2025360-91-0 98%
(R)-Azasetron besylate
(R)-Azasetron besylate (SENS-401), an orally active calcineurin inhibitor, has been shown to mitigate cisplatin-induced hearing loss and cochlear damage [1][2].
T78681 ITH12711 98%
ITH12711
ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].
T78702 PTP1B/AKR1B1-IN-1 98%
PTP1B/AKR1B1-IN-1
PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s o...
T78703 PTP1B/AKR1B1-IN-2 98%
PTP1B/AKR1B1-IN-2
PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and...
T79049 Tegeprotafib 2407610-46-0 98%
Tegeprotafib
Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active inhibitor targeting both PTPN2 and PTPN1B, displaying potent IC50 values at 4.4 nM for PTPN2 and 1...
T79160 PROTAC PTPN2 degrader-2 2912307-38-9 98%
PROTAC PTPN2 degrader-2
PROTAC PTPN2 degrader-2 (example 187B) is a potent agent capable of degrading PTPN2, which holds potential for research in cancer and metabolic diseases [1].
T79161 PROTAC PTPN2 degrader-2 TFA 2912307-39-0 98%
PROTAC PTPN2 degrader-2 TFA
PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent degrader of Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2), with potential applications in cance...
T79491 H-NTPDase-IN-1 98%
h-NTPDase-IN-1
h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase (h-NTPDase) with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating its p...
T79623 H-NTPDase-IN-5 2939932-93-9 98%
h-NTPDase-IN-5
h-NTPDase-IN-5 (compound 3b) serves as a pan-inhibitor of NTPDase, exhibiting inhibitory concentration 50 (IC50) values of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPD...
T79634 LYP-IN-3 98%
LYP-IN-3
LYP-IN-3 (compound D34) is a selective Lymphoid-tyrosine phosphatase (LYP) inhibitor (Ki=0.93 μM) that modulates the T-cell receptor (TCR) signaling pathway duri...
T79635 LYP-IN-4 98%
LYP-IN-4
LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1...
T79843 Anticancer agent 142 2948338-60-9 98%
Anticancer agent 142
Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].
T79844 Anticancer agent 143 2948339-38-4 98%
Anticancer agent 143
Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM. It is employed in cancer research [1]....
T79845 Anticancer agent 144 2948340-59-6 98%
Anticancer agent 144
Compound 144 (also known as Anticancer Agent 144) is a potent inhibitor of both PTPN2 and PTP1B, exhibiting IC50 values of less than 2.5 nM, making it suitable f...
T79985 Cryptosporioptide A 1647101-05-0 98%
Cryptosporioptide A
Cryptosporioptide A (Compound 3), a protein tyrosine phosphatase inhibitor, originates from the insect-parasitic fungus Cordyceps gracilioides. This compound eff...
T80007 Stevisalioside A 98%
Stevisalioside A
Stevisalioside A (Compound 2), isolated from the roots of Stevia serrata, is an orally active antidiabetic agent that inhibits Protein Tyrosine Phosphatase 1B (P...
T80008 Stevisaliosides D 98%
Stevisaliosides D
Stevisaliosides D (Compound 5), extracted from the roots of Stevia serrata, exhibits inhibition of PTP1B with an IC50 of 31.8 μM and has applications in antidiab...
TD52
T35528
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
PTP1B-IN-4
T24073
PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
Rhein-8-glucoside calcium
T3827
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt) shows moderate bioactivity against human Protein Tyrosine Phosp...
(R)-Azasetron besylate
T78217
(R)-Azasetron besylate (SENS-401), an orally active calcineurin inhibitor, has been shown to mitigate cisplatin-induced hearing loss and cochlear damage [1][2].
ITH12711
T78681
ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].
PTP1B/AKR1B1-IN-1
T78702
PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s o...
PTP1B/AKR1B1-IN-2
T78703
PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and...
Tegeprotafib
T79049
Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active inhibitor targeting both PTPN2 and PTPN1B, displaying potent IC50 values at 4.4 nM for PTPN2 and 1...
PROTAC PTPN2 degrader-2
T79160
PROTAC PTPN2 degrader-2 (example 187B) is a potent agent capable of degrading PTPN2, which holds potential for research in cancer and metabolic diseases [1].
PROTAC PTPN2 degrader-2 TFA
T79161
PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent degrader of Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2), with potential applications in cance...
h-NTPDase-IN-1
T79491
h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase (h-NTPDase) with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating its p...
h-NTPDase-IN-5
T79623
h-NTPDase-IN-5 (compound 3b) serves as a pan-inhibitor of NTPDase, exhibiting inhibitory concentration 50 (IC50) values of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPD...
LYP-IN-3
T79634
LYP-IN-3 (compound D34) is a selective Lymphoid-tyrosine phosphatase (LYP) inhibitor (Ki=0.93 μM) that modulates the T-cell receptor (TCR) signaling pathway duri...
LYP-IN-4
T79635
LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1...
Anticancer agent 142
T79843
Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].
Anticancer agent 143
T79844
Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM. It is employed in cancer research [1]....
Anticancer agent 144
T79845
Compound 144 (also known as Anticancer Agent 144) is a potent inhibitor of both PTPN2 and PTP1B, exhibiting IC50 values of less than 2.5 nM, making it suitable f...
Cryptosporioptide A
T79985
Cryptosporioptide A (Compound 3), a protein tyrosine phosphatase inhibitor, originates from the insect-parasitic fungus Cordyceps gracilioides. This compound eff...
Stevisalioside A
T80007
Stevisalioside A (Compound 2), isolated from the roots of Stevia serrata, is an orally active antidiabetic agent that inhibits Protein Tyrosine Phosphatase 1B (P...
Stevisaliosides D
T80008
Stevisaliosides D (Compound 5), extracted from the roots of Stevia serrata, exhibits inhibition of PTP1B with an IC50 of 31.8 μM and has applications in antidiab...
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TargetMol