Home Tools
Log in
Cart

Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3564 SHP099 1801747-42-1 98.73%
SHP099
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells ...
T14841 BVT948 39674-97-0 98.70%
BVT948
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
T7381 TCS 401 243966-09-8 98.65%
TCS 401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
T4449 LB100 1632032-53-1 98.63%
LB100
LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor.
T7150 BTdCPU 1257423-87-2 98.61%
BTdCPU
BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
T0494 Tetramisole hydrochloride 5086-74-8 98.6%
Tetramisole hydrochloride
Tetramisole hydrochloride (Tetramisole HCl) inhibits alkaline phosphatase and is a high-purity antiparasitic agent.
T2417 Sal003 1164470-53-4 98.58%
Sal003
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
T23132 Pentamidine dihydrochloride 50357-45-4 98.58%
Pentamidine dihydrochloride
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypa...
T11139 (E/Z)-BCI 15982-84-0 98.55%
(E/Z)-BCI
(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS ...
T26684 Auten-99 HBr 1049780-58-6 98.37%
Auten-99 HBr
Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and ...
T6667 SF1670 345630-40-2 98.25%
SF1670
SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
T19389 L-Ascorbic acid 2-phosphate magnesium 113170-55-1 98.23%
L-Ascorbic acid 2-phosphate magnesium
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production....
T11053 DJ001 2161305-12-8 98.21%
DJ001
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with IC50 of 1.43 μM. DJ001 promotes the regeneration o...
T23133 Pentamidine 100-33-4 98.13%
Pentamidine
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor gro...
T13410 ZLDI-8 667880-38-8 98.09%
ZLDI-8
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T67893 PTP1B-IN-22 86109-60-6 98.05%
PTP1B-IN-22
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
T11929 M2N12 2376577-06-7 98.01%
M2N12
M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selectiv...
T5891 D-ERYTHRO-SPHINGOSINE 123-78-4 98.00%
D-ERYTHRO-SPHINGOSINE
D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
T6911 NSC-87877 disodium 56932-43-5 98%
NSC-87877 disodium
NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced...
T0945 Cyclosporin A 59865-13-3 98%
Cyclosporin A
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procycli...
SHP099
T3564
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells ...
BVT948
T14841
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
TCS 401
T7381
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
LB100
T4449
LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor.
BTdCPU
T7150
BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
Tetramisole hydrochloride
T0494
Tetramisole hydrochloride (Tetramisole HCl) inhibits alkaline phosphatase and is a high-purity antiparasitic agent.
Sal003
T2417
Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.
Pentamidine dihydrochloride
T23132
Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypa...
(E/Z)-BCI
T11139
(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS ...
Auten-99 HBr
T26684
Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and ...
SF1670
T6667
SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
L-Ascorbic acid 2-phosphate magnesium
T19389
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production....
DJ001
T11053
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase σ (PTPσ) inhibitor with IC50 of 1.43 μM. DJ001 promotes the regeneration o...
Pentamidine
T23133
Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor gro...
ZLDI-8
T13410
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
PTP1B-IN-22
T67893
PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.
M2N12
T11929
M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selectiv...
D-ERYTHRO-SPHINGOSINE
T5891
D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
NSC-87877 disodium
T6911
NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced...
Cyclosporin A
T0945
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procycli...
1 2 3 4 5 6 7 8
TargetMol