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Potassium Channel

Potassium Channels. K+ channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, and thus generate electrical signals in cells. Voltage-gated K+ channels (Kv channels), present in all animal cells, open and close upon changes in the transmembrane potential.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2434 LY 303511 154447-38-8 99.91%
LY 303511
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
TN3910 Ecdysone 3604-87-3 100%
Ecdysone
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signal...
TN3042 4-Hydroxycinnamamide 194940-15-3 98%
4-Hydroxycinnamamide
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
T78062 Dendrotoxin K TFA 98%
Dendrotoxin K TFA
Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].
T78523 Clobutinol hydrochloride 1215-83-4 98%
Clobutinol hydrochloride
Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].
T78868 TWIK-1/TREK-1-IN-1 1440532-30-8 98%
TWIK-1/TREK-1-IN-1
Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWI...
T78869 TWIK-1/TREK-1-IN-2 1440532-32-0 98%
TWIK-1/TREK-1-IN-2
TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values ...
T79445 KV1.3-IN-1 98%
KV1.3-IN-1
KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in Ltk cells and 26.12 nM in PHA-activated T-lymphocytes, disrupts...
T80028 Iberiotoxin TFA 98%
Iberiotoxin TFA
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet it ...
T80034 Margatoxin TFA 98%
Margatoxin TFA
Margatoxin TFA, an alpha-KTx scorpion toxin isolated from Centruroides margaritatus venom, is a 39-amino-acid peptide that serves as a high-affinity inhibitor of...
T80036 AmmTX3 TFA 98%
AmmTX3 TFA
AmmTX3 TFA, a peptide toxin derived from Androctonus mauretanicus scorpion venom, functions as a selective blocker of the K_v4 channel. It inhibits the A-type K^...
T80050 Noxiustoxin 85205-49-8 98%
Noxiustoxin
Noxiustoxin, a toxin extracted from the venom of the Mexican scorpion Centruroides noxius, inhibits both the voltage-dependent potassium channel (Kv1.3, IC50 = 3...
T80053 Phrixotoxin-1 221872-97-5 98%
Phrixotoxin-1
Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels, originates from the venom of the theraphosid spider Phrixotrichus auratus [1] [2].
T80054 Phrixotoxin 2 741738-57-8 98%
Phrixotoxin 2
Phrixotoxin 2 selectively blocks the KV 4.2 and KV 4.3 channels, demonstrating high specificity in its interaction with these voltage-gated ion channels [1].
T80058 Pandinotoxin Kα 185529-64-0 98%
Pandinotoxin Kα
Pandinotoxin Kα, a chemical compound extracted from the emperor scorpion (Pandinus imperator) venom, functions as an inhibitor of the A-type potassium channel [1...
T80061 Hongotoxin-1 98%
Hongotoxin-1
Hongotoxin-1, a chemical compound isolated from the venom of Centruroides limbatus, functions as a potassium channel inhibitor. It exhibits inhibitory concentrat...
T80064 Dendrotoxin-I 107950-33-4 98%
Dendrotoxin-I
Dendrotoxin-I, a neurotoxin from Dendroaspis snake venom, potently blocks K⁺ channels, specifically targeting voltage-gated potassium channel subunits KV1.1 and ...
T80066 ShK toxin 172450-46-3 98%
ShK toxin
ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel). It com...
T80068 Slotoxin 98%
Slotoxin
Slotoxin, a peptide extracted from the venom of the Centruroides noxius Hoffmann scorpion, inhibits high-conductance calcium-activated potassium channels with a ...
T80170 Tamapin 98%
Tamapin
Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated K(+) (...
LY 303511
T2434
LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
Ecdysone
TN3910
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signal...
4-Hydroxycinnamamide
TN3042
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
Dendrotoxin K TFA
T78062
Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].
Clobutinol hydrochloride
T78523
Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].
TWIK-1/TREK-1-IN-1
T78868
Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWI...
TWIK-1/TREK-1-IN-2
T78869
TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values ...
KV1.3-IN-1
T79445
KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in Ltk cells and 26.12 nM in PHA-activated T-lymphocytes, disrupts...
Iberiotoxin TFA
T80028
Iberiotoxin (TFA) is a selective inhibitor of high conductance Ca2+-activated K+ channels, exhibiting a dissociation constant (Kd) of approximately 1 nM, yet it ...
Margatoxin TFA
T80034
Margatoxin TFA, an alpha-KTx scorpion toxin isolated from Centruroides margaritatus venom, is a 39-amino-acid peptide that serves as a high-affinity inhibitor of...
AmmTX3 TFA
T80036
AmmTX3 TFA, a peptide toxin derived from Androctonus mauretanicus scorpion venom, functions as a selective blocker of the K_v4 channel. It inhibits the A-type K^...
Noxiustoxin
T80050
Noxiustoxin, a toxin extracted from the venom of the Mexican scorpion Centruroides noxius, inhibits both the voltage-dependent potassium channel (Kv1.3, IC50 = 3...
Phrixotoxin-1
T80053
Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels, originates from the venom of the theraphosid spider Phrixotrichus auratus [1] [2].
Phrixotoxin 2
T80054
Phrixotoxin 2 selectively blocks the KV 4.2 and KV 4.3 channels, demonstrating high specificity in its interaction with these voltage-gated ion channels [1].
Pandinotoxin Kα
T80058
Pandinotoxin Kα, a chemical compound extracted from the emperor scorpion (Pandinus imperator) venom, functions as an inhibitor of the A-type potassium channel [1...
Hongotoxin-1
T80061
Hongotoxin-1, a chemical compound isolated from the venom of Centruroides limbatus, functions as a potassium channel inhibitor. It exhibits inhibitory concentrat...
Dendrotoxin-I
T80064
Dendrotoxin-I, a neurotoxin from Dendroaspis snake venom, potently blocks K⁺ channels, specifically targeting voltage-gated potassium channel subunits KV1.1 and ...
ShK toxin
T80066
ShK toxin, isolated from the Caribbean sea anemone (Stichodactyla helianthus), is an inhibitor of the voltage-dependent potassium channel (Kv1.3 channel). It com...
Slotoxin
T80068
Slotoxin, a peptide extracted from the venom of the Centruroides noxius Hoffmann scorpion, inhibits high-conductance calcium-activated potassium channels with a ...
Tamapin
T80170
Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated K(+) (...
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TargetMol