Potassium Channel

Potassium Channels. K+ channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, and thus generate electrical signals in cells. Voltage-gated K+ channels (Kv channels), present in all animal cells, open and close upon changes in the transmembrane potential.

Cat. No.	Product name	CAS No.	Purity
T4316	ML365	947914-18-3	99.91%
T4316	ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
T72066	CHET3	2489231-47-0	99.91%
T72066	CHET3 is a TASK-3 inhibitor that can be used to study pain.
T1073	Dronedarone hydrochloride	141625-93-6	99.91%
T1073	Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T22826	GW 542573X	660846-41-3	99.91%
T22826	GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curve of...
T3876	Loureirin B	119425-90-0	99.91%
T3876	Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress...
TQ0150	Levcromakalim	94535-50-9	99.91%
TQ0150	Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.
T3054	Daurisoline	70553-76-3	99.90%
T3054	Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.
T13320L	VU591	1222810-74-3	99.9%
T13320L	1222810-74-3
T10977	DCEBIO	60563-36-2	99.89%
T10977	DCEBIO stimulates the secretion of Cl- through the activation of the hIK1 K + channel and the activation of the apical Cl- conductance. DCEBIO is a derivative of...
T1050	Prazosin hydrochloride	19237-84-4	99.87%
T1050	Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism n...
T27753	KT-362 fumarate	105394-80-7	99.87%
T27753	KT-362 fumarate is a novel compound that acts as an antagonist of calcium channels, potassium channels and sodium channels.KT-362 fumarate causes vasodilation by...
TN1092	O-Nornuciferine	3153-55-7	99.86%
TN1092	O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
T8182	Guanfu base A	1394-48-5	99.85%
T8182	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
T2170	SKF-96365 hydrochloride	130495-35-1	99.85%
T2170	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells...
T12256	NS8593 hydrochloride	875755-24-1	99.83%
T12256	NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
T2280	Endoxifen (Z-isomer)	112093-28-4	99.81%
T2280	Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase ac...
T6592	ML133 hydrochloride	1222781-70-5	99.81%
T6592	ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 a...
T1676	Rosuvastatin	287714-41-4	99.8%
T1676	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the...
TNU0864	HUP30	312747-21-0	99.8%
TNU0864	HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.
T24799	SKA-111	1369170-24-0	99.79%
T24799	SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial c...