Potassium Channel

Potassium Channels. K+ channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, and thus generate electrical signals in cells. Voltage-gated K+ channels (Kv channels), present in all animal cells, open and close upon changes in the transmembrane potential.

Cat. No.	Product name	CAS No.	Purity
T1266	Terfenadine	50679-08-8	99.36%
T1266	Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist...
T1146	Nifedipine	21829-25-4	99.30%
T1146	Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myoca...
T8700	TKIM	326921-25-9	99.3%
T8700	TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.
T1498	Indapamide	26807-65-8	99.28%
T1498	Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure....
T67917	ML353		99.28%
T67917	ML353 (VU0478006) is a selective activator of TREK-1 and TREK-2 and a selective ligand (Ki =18.2 nM) for the mGlu5 Silencing Allosteric Modulator (SAM). ML353 ha...
T0974	Novobiocin Sodium	1476-53-5	99.28%
T0974	Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
T11515	Gut restricted-7	2553218-46-3	99.27%
T11515	Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugate...
T15286	Flindokalner	187523-35-9	99.25%
T15286	Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner ...
TP1852L	Myomodulin acetate(110570-93-9 free base)	TP1852L	99.24%
TP1852L	Myomodulin acetate is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10.
T11529	H3B-120	2194903-42-7	99.2%
T11529	H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity...
T0816	Acetohexamide	968-81-0	99.19%
T0816	Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) link...
T1049	Oxybutynin chloride	1508-65-2	99.17%
T1049	Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, ...
T3465L	Vesnarinone HCl	T3465L	99.17%
T3465L	Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium ...
T1453	Phenformin hydrochloride	834-28-6	99.15%
T1453	Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.
T7775	A2764 dihydrochloride	861038-72-4	99.08%
T7775	A2764 dihydrochloride is a highly selective inhibitor of TRESK.
T4369	SCH-23390 hydrochloride	125941-87-9	99.07%
T4369	SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM).
T6476	Dofetilide	115256-11-6	99.06%
T6476	Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the ra...
T17227	Vernakalant Hydrochloride	748810-28-8	99.04%
T17227	Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.
T78870	TWIK-1/TREK-1-IN-3	1440532-33-1	99.04%
T78870	TWIK-1/TREK-1-IN-3 is a selective and potent inhibitor of potassium channel TREK-1, inhibiting TREK-1 homodimers and TWIK-1/TREK-1 heterodimers containing two-po...
T6631	Quinine hydrochloride dihydrate	6119-47-7	99.04%
T6631	Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.