Home Tools
Log in
Cart

Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6475 (±)-Carnitine chloride 461-05-2 98%
(±)-Carnitine chloride
(±)-Carnitine chloride (Monocamin) is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.
T7191 Diphenyleneiodonium chloride 4673-26-1 98%
Diphenyleneiodonium chloride
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum...
T7781 Reynoutrin 549-32-6 97.98%
Reynoutrin
Reynoutrin (Reinutrin) with antioxidant and radical-scavenging activity.
T6S1367 Procyanidin B2 29106-49-8 97.69%
Procyanidin B2
Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin ...
T2587 Ecabet Sodium 86408-72-2 97.68%
Ecabet Sodium
Ecabet Sodium (TA-2711) is a potential new agent in the management of distal colitis.
T22235 Lipoic acid 1200-22-2 97.66%
Lipoic acid
Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism...
T8370 GSK5182 877387-37-6 97.63%
GSK5182
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
T9211 Mito-LND 2361564-49-8 97.27%
Mito-LND
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T67498 3-Amino-1,2,4-triazole 61-82-5 97.16%
3-Amino-1,2,4-triazole
3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. Th...
T12059L Mitoquinone mesylate 845959-50-4 97.12%
Mitoquinone mesylate
Mitoquinone mesylate (MitoQ10 mesylate) is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
T1035 Hesperidin 520-26-3 97.05%
Hesperidin
Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowe...
T6699 Tempol 2226-96-2 97%
Tempol
Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
T8320 J14 1043854-13-2 96.93%
J14
J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading...
T3240 Citronellol 106-22-9 96.38%
Citronellol
Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant.
T0756 Ethoxyquin 91-53-2 95.94%
Ethoxyquin
Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
T5645 Nerol 106-25-2 95.71%
Nerol
Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias ...
T1080 2-Aminoethanethiol 60-23-1 95.00%
2-Aminoethanethiol
2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
T6460 Cysteamine hydrochloride 156-57-0 95%
Cysteamine hydrochloride
Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant.
T0492 Dimethyl fumarate 624-49-7 90.51%
Dimethyl fumarate
Dimethyl fumarate (DMF), a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
TN4782 Picein 530-14-3 100%
Picein
Picein (Piceoside) is derived from Picrorhiza kurroa and shows antioxidant properties.
(±)-Carnitine chloride
T6475
(±)-Carnitine chloride (Monocamin) is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.
Diphenyleneiodonium chloride
T7191
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum...
Reynoutrin
T7781
Reynoutrin (Reinutrin) with antioxidant and radical-scavenging activity.
Procyanidin B2
T6S1367
Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin ...
Ecabet Sodium
T2587
Ecabet Sodium (TA-2711) is a potential new agent in the management of distal colitis.
Lipoic acid
T22235
Lipoic acid (R-(+)-Thioctic acid) is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism...
GSK5182
T8370
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
Mito-LND
T9211
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
3-Amino-1,2,4-triazole
T67498
3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. Th...
Mitoquinone mesylate
T12059L
Mitoquinone mesylate (MitoQ10 mesylate) is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
Hesperidin
T1035
Hesperidin (Cirantin) is a flavanone glycoside found in citrus fruits with antioxidant, anti-inflammatory, anti-carcinogenic, and antihypertensive and lipid-lowe...
Tempol
T6699
Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
J14
T8320
J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading...
Citronellol
T3240
Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant.
Ethoxyquin
T0756
Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
Nerol
T5645
Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias ...
2-Aminoethanethiol
T1080
2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
Cysteamine hydrochloride
T6460
Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant.
Dimethyl fumarate
T0492
Dimethyl fumarate (DMF), a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
Picein
TN4782
Picein (Piceoside) is derived from Picrorhiza kurroa and shows antioxidant properties.
1 2 3 4 5 6 7 8 9 10 11 12
TargetMol