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Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T80027 Palmitoyl tripeptide-38 1447824-23-8 98%
Palmitoyl tripeptide-38
Palmitoyl tripeptide-38 is a bioactive peptide renowned for its anti-aging properties [1].
T80204 Octapeptide-2 1374396-34-5 98%
Octapeptide-2
Octapeptide-2 is a bioactive peptide known for its hair growth-promoting effects and is reported to be used as a cosmetic ingredient [1].
T82972 Argininosuccinic acid disodium 918149-29-8 98%
Argininosuccinic acid disodium
Argininosuccinic acid disodium, involved in the urea cycle's fourth step, is cleaved by argininosuccinate lyase (ASL) into arginine and fumarate. It diminishes r...
T75000 Mal-Pc 2670367-74-3 98%
Mal-Pc
Mal-Pc, a phthalocyanine-based molecular photosensitizer featuring maleimides, interacts with GSH to diminish its levels and decrease aggregation, enhancing the ...
T8306 Epiberberine chloride 889665-86-5 98%
Epiberberine chloride
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
T21338 Methylprednisolone Acetate 53-36-1 98%
Methylprednisolone Acetate
Methylprednisolone Acetate(Depo-Medrate) has the ability to inhibit oxygen free radicals and can be used to treat acute spinal cord injuries.
T37710 5-Hydroxyoxindole 3416-18-0 98%
5-Hydroxyoxindole
5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. ...
T8132 Iron sucrose 8047-67-4 Sucrose>=80%,Iron 5%~6%
Iron sucrose
Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.
TN2167 Rutaevin 33237-37-5 99.99%
Rutaevin
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
T5116 Iprodione 36734-19-7 99.98%
Iprodione
Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.
T4S1659 Xanthotoxol 2009-24-7 99.97%
Xanthotoxol
Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic...
T3332 Isosteviol 27975-19-5 99.97%
Isosteviol
Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside ...
T3730 Methyl gallate 99-24-1 99.96%
Methyl gallate
Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
T0877 Gallic acid 149-91-7 99.95%
Gallic acid
Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T3744 Veratric acid 93-07-2 99.95%
Veratric acid
Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowerin...
T2220 2-Methoxyestradiol 362-07-2 99.95%
2-Methoxyestradiol
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by red...
TN1674 Garcinone D 107390-08-9 99.94%
Garcinone D
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
T9057 Norbergenin 79595-97-4 99.93%
norbergenin
Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
T3753 Sinapinic Acid 530-59-6 99.92%
Sinapinic Acid
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p6...
T41242 Uric acid sodium 1198-77-2 99.92%
Uric acid sodium
Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric a...
Palmitoyl tripeptide-38
T80027
Palmitoyl tripeptide-38 is a bioactive peptide renowned for its anti-aging properties [1].
Octapeptide-2
T80204
Octapeptide-2 is a bioactive peptide known for its hair growth-promoting effects and is reported to be used as a cosmetic ingredient [1].
Argininosuccinic acid disodium
T82972
Argininosuccinic acid disodium, involved in the urea cycle's fourth step, is cleaved by argininosuccinate lyase (ASL) into arginine and fumarate. It diminishes r...
Mal-Pc
T75000
Mal-Pc, a phthalocyanine-based molecular photosensitizer featuring maleimides, interacts with GSH to diminish its levels and decrease aggregation, enhancing the ...
Epiberberine chloride
T8306
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
Methylprednisolone Acetate
T21338
Methylprednisolone Acetate(Depo-Medrate) has the ability to inhibit oxygen free radicals and can be used to treat acute spinal cord injuries.
5-Hydroxyoxindole
T37710
5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. ...
Iron sucrose
T8132
Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.
Rutaevin
TN2167
Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflamm...
Iprodione
T5116
Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.
Xanthotoxol
T4S1659
Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic...
Isosteviol
T3332
Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside ...
Methyl gallate
T3730
Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
Gallic acid
T0877
Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
Veratric acid
T3744
Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowerin...
2-Methoxyestradiol
T2220
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by red...
Garcinone D
TN1674
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
norbergenin
T9057
Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
Sinapinic Acid
T3753
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p6...
Uric acid sodium
T41242
Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric a...
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TargetMol