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Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Cat. No. Product name CAS No. Purity Chemical Structure
TL0006 Cichoric Acid 6537-80-0 98%
Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics...
T2997 Rhein 478-43-3 98%
Rhein is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
T5736 1,3-Dicaffeoylquinic acid 19870-46-3 98%
CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
T15433 GSK2795039 1415925-18-6 98%
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
T15212 Emamectin Benzoate 155569-91-8 98%
Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as ...
T3S1089 Phillygenin 487-39-8 98%
1. Phillyrin, (+)-Phillygenin, and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.
T2866 Echinocystic acid 510-30-5 98%
Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant e...
T0418 Allylthiourea 109-57-9 98%
Allylthiourea, a metabolic inhibitor, specifically suppresses ammonia oxidation.
T3399 Psoralidin 18642-23-4 98%
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
T8347 Rifamycin S 13553-79-2 98%
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
T5016 Tofogliflozin (hydrate) 1201913-82-7 98%
Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
T15213 Emeramide 351994-94-0 98%
Emeramide is a thiol-redox antioxidant. It is also a heavy metal chelator.
T22235 Lipoic acid 1200-22-2 98%
Lipoic acid is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
T2838 Naringenin 480-41-1 98%
Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate me...
T67927 BAY-069 2639638-66-5 98%
BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at...
T2992 Pinocembrin 480-39-7 98%
Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
T2834 Nobiletin 478-01-3 98%
Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
T2871 Quercitrin 522-12-3 98%
Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
T2799 (20S)-Protopanaxadiol 30636-90-9 98%
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
T6201 Disufenton sodium 168021-79-2 98%
NXY-059, a new-type nitrone, exhibits potently neuroprotective effects.
Cichoric Acid
TL0006
Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics...
Rhein
T2997
Rhein is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
1,3-Dicaffeoylquinic acid
T5736
CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
GSK2795039
T15433
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
Emamectin Benzoate
T15212
Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as ...
Phillygenin
T3S1089
1. Phillyrin, (+)-Phillygenin, and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.
Echinocystic acid
T2866
Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant e...
Allylthiourea
T0418
Allylthiourea, a metabolic inhibitor, specifically suppresses ammonia oxidation.
Psoralidin
T3399
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
Rifamycin S
T8347
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
Tofogliflozin (hydrate)
T5016
Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
Emeramide
T15213
Emeramide is a thiol-redox antioxidant. It is also a heavy metal chelator.
Lipoic acid
T22235
Lipoic acid is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
Naringenin
T2838
Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate me...
BAY-069
T67927
BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at...
Pinocembrin
T2992
Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
Nobiletin
T2834
Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
Quercitrin
T2871
Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
(20S)-Protopanaxadiol
T2799
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
Disufenton sodium
T6201
NXY-059, a new-type nitrone, exhibits potently neuroprotective effects.
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