Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No.	Product name	CAS No.	Purity
TL0006	Cichoric Acid	6537-80-0	98%
TL0006	Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics...
T2997	Rhein	478-43-3	98%
T2997	Rhein is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
T5736	1,3-Dicaffeoylquinic acid	19870-46-3	98%
T5736	CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
T15433	GSK2795039	1415925-18-6	98%
T15433	GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
T15212	Emamectin Benzoate	155569-91-8	98%
T15212	Emamectin Benzoate, by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as ...
T3S1089	Phillygenin	487-39-8	98%
T3S1089	1. Phillyrin, (+)-Phillygenin, and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.
T2866	Echinocystic acid	510-30-5	98%
T2866	Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant e...
T0418	Allylthiourea	109-57-9	98%
T0418	Allylthiourea, a metabolic inhibitor, specifically suppresses ammonia oxidation.
T3399	Psoralidin	18642-23-4	98%
T3399	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
T8347	Rifamycin S	13553-79-2	98%
T8347	Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
T5016	Tofogliflozin (hydrate)	1201913-82-7	98%
T5016	Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
T15213	Emeramide	351994-94-0	98%
T15213	Emeramide is a thiol-redox antioxidant. It is also a heavy metal chelator.
T22235	Lipoic acid	1200-22-2	98%
T22235	Lipoic acid is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism.
T2838	Naringenin	480-41-1	98%
T2838	Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate me...
T67927	BAY-069	2639638-66-5	98%
T67927	BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at...
T2992	Pinocembrin	480-39-7	98%
T2992	Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.
T2834	Nobiletin	478-01-3	98%
T2834	Nobiletin is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (...
T2871	Quercitrin	522-12-3	98%
T2871	Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
T2799	(20S)-Protopanaxadiol	30636-90-9	98%
T2799	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
T6201	Disufenton sodium	168021-79-2	98%
T6201	NXY-059, a new-type nitrone, exhibits potently neuroprotective effects.