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Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Cat. No. Product name CAS No. Purity Chemical Structure
T4749 Squalene 111-02-4 98%
Squalene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, in...
T2941 Glucosamine hydrochloride 66-84-2 98%
Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T3759 3,4-Dimethoxycinnamic acid 2316-26-9 98%
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effect...
T35749 Thymohydroquinone 2217-60-9 98%
Thymohydroquinone is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell ...
T6S1653 Albiflorin 39011-90-0 98%
1. Albiflorin has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoni...
TQ0212 Glucoraphanin 21414-41-5 98%
Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
TN5634 Aureusidin 38216-54-5 98%
Aureusidin shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.
T1085 L-Glutathione reduced 70-18-8 98%
Glutathione is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved...
T6S1367 Procyanidin B2 29106-49-8 98%
Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inf...
T2090 Lexibulin 917111-44-5 98%
Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and lea...
T3417 Amentoflavone 1617-53-4 98%
Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in t...
T7461 2,4-Diamino-6-hydroxypyrimidine 56-06-4 98%
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
T13396 Zinc Protoporphyrin 15442-64-5 98%
Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG...
T6S1917 Schisandrol B 58546-54-6 98%
1. Gomisin A may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs ...
T3330 Trans-Trimethoxyresveratrol 22255-22-7 98%
3, 5, 4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin si...
T3496 Buprofezin 69327-76-0 98%
Buprofezin is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.
T4S0797 Berberine 2086-83-1 98%
1. Berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a com...
T2821 Ethyl ferulate 4046-02-0 98%
Ethyl ferulate is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective...
T5426 DMNQ 6956-96-3 98%
DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS...
TN6735 Bigelovin 3668-14-2 98%
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pat...
Squalene
T4749
Squalene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, in...
Glucosamine hydrochloride
T2941
Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
3,4-Dimethoxycinnamic acid
T3759
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effect...
Thymohydroquinone
T35749
Thymohydroquinone is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell ...
Albiflorin
T6S1653
1. Albiflorin has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoni...
Glucoraphanin
TQ0212
Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
Aureusidin
TN5634
Aureusidin shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.
L-Glutathione reduced
T1085
Glutathione is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved...
Procyanidin B2
T6S1367
Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inf...
Lexibulin
T2090
Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and lea...
Amentoflavone
T3417
Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in t...
2,4-Diamino-6-hydroxypyrimidine
T7461
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
Zinc Protoporphyrin
T13396
Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG...
Schisandrol B
T6S1917
1. Gomisin A may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs ...
trans-Trimethoxyresveratrol
T3330
3, 5, 4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin si...
Buprofezin
T3496
Buprofezin is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.
Berberine
T4S0797
1. Berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a com...
Ethyl ferulate
T2821
Ethyl ferulate is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective...
DMNQ
T5426
DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS...
Bigelovin
TN6735
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pat...
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