Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No.	Product name	CAS No.	Purity
T4749	Squalene	111-02-4	98%
T4749	Squalene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, in...
T2941	Glucosamine hydrochloride	66-84-2	98%
T2941	Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T3759	3,4-Dimethoxycinnamic acid	2316-26-9	98%
T3759	3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effect...
T35749	Thymohydroquinone	2217-60-9	98%
T35749	Thymohydroquinone is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell ...
T6S1653	Albiflorin	39011-90-0	98%
T6S1653	1. Albiflorin has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoni...
TQ0212	Glucoraphanin	21414-41-5	98%
TQ0212	Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
TN5634	Aureusidin	38216-54-5	98%
TN5634	Aureusidin shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.
T1085	L-Glutathione reduced	70-18-8	98%
T1085	Glutathione is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved...
T6S1367	Procyanidin B2	29106-49-8	98%
T6S1367	Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inf...
T2090	Lexibulin	917111-44-5	98%
T2090	Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and lea...
T3417	Amentoflavone	1617-53-4	98%
T3417	Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in t...
T7461	2,4-Diamino-6-hydroxypyrimidine	56-06-4	98%
T7461	2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis
T13396	Zinc Protoporphyrin	15442-64-5	98%
T13396	Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG...
T6S1917	Schisandrol B	58546-54-6	98%
T6S1917	1. Gomisin A may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs ...
T3330	Trans-Trimethoxyresveratrol	22255-22-7	98%
T3330	3, 5, 4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin si...
T3496	Buprofezin	69327-76-0	98%
T3496	Buprofezin is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.
T4S0797	Berberine	2086-83-1	98%
T4S0797	1. Berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a com...
T2821	Ethyl ferulate	4046-02-0	98%
T2821	Ethyl ferulate is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective...
T5426	DMNQ	6956-96-3	98%
T5426	DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS...
TN6735	Bigelovin	3668-14-2	98%
TN6735	Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pat...