Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No.	Product name	CAS No.	Purity
TN5634	Aureusidin	38216-54-5	99.18%
TN5634	Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.
T5852	Canthaxanthin	514-78-3	99.1%
T5852	Canthaxanthin (E 161g) is a red-orange carotenoid that belongs to the xanthophyll group. This naturally occurring pigment is present in bacteria, algae and some ...
T35749	Thymohydroquinone	2217-60-9	99.08%
T35749	Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibit...
T3759	3,4-Dimethoxycinnamic acid	2316-26-9	99.07%
T3759	3,4-Dimethoxycinnamic acid (O-Methylferulic acid) (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exert...
T2941	Glucosamine hydrochloride	66-84-2	99.07%
T2941	Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T2925	Schisandrin B	61281-37-6	99.02%
T2925	Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.
T6201	Disufenton sodium	168021-79-2	99%
T6201	Disufenton sodium (NXY-059), a new-type nitrone, exhibits potently neuroprotective effects.
T0933	D-(+)-Glucono-1,5-lactone	90-80-2	99%
T0933	D-(+)-Glucono-1,5-lactone (Gluconolactone) is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent....
T0875	Acetylcysteine	616-91-1	98.98%
T0875	Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
T2799	(20S)-Protopanaxadiol	30636-90-9	98.91%
T2799	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginse...
T2834	Nobiletin	478-01-3	98.88%
T2834	Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is pr...
TN6706	3-demethylcolchicine	7336-33-6	98.87%
TN6706	3-demethylcolchicine is a natural product isolated from Gloriosa superba.Inhibitory effect on the polymerization of purified bovine brain tubulin.
TQ0212	Glucoraphanin	21414-41-5	98.86%
TQ0212	Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
T67927	BAY-069	2639638-66-5	98.83%
T67927	BAY-069 is an inhibitor. BAY-069 inhibited branched-chain amino acid transaminase 1 (BCAT1) at IC50:31 nM and branched-chain amino acid transaminase 2 (BCAT2) at...
T2838	Naringenin	480-41-1	98.81%
T2838	Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, car...
T4287	Succinobucol	216167-82-7	98.8%
T4287	Succinobucol (Probucol monosuccinate) is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat ath...
T15213	Emeramide	351994-94-0	98.8%
T15213	Emeramide (BDTH2) is a thiol-redox antioxidant. It is also a heavy metal chelator.
T5016	Tofogliflozin (hydrate)	1201913-82-7	98.78%
T5016	Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human,...
T8347	Rifamycin S	13553-79-2	98.76%
T8347	Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
T1085	L-Glutathione reduced	70-18-8	98.72%
T1085	L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals. L-Glutat...