Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No.	Product name	CAS No.	Purity
T0418	Allylthiourea	109-57-9	98.71%
T0418	Allylthiourea (Thiosinamine), a metabolic inhibitor, specifically suppresses ammonia oxidation.
T2866	Echinocystic acid	510-30-5	98.7%
T2866	Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant e...
T3S1089	Phillygenin	487-39-8	98.7%
T3S1089	1. Phillyrin, (+)-Phillygenin (Sylvatesmin), and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.
T15212	Emamectin Benzoate	155569-91-8	98.68%
T15212	Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods,...
T15433	GSK2795039	1415925-18-6	98.68%
T15433	GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
T5736	1,3-Dicaffeoylquinic acid	19870-46-3	98.68%
T5736	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
T2997	Rhein	478-43-3	98.66%
T2997	Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.
T1716	Echinacoside	82854-37-3	98.58%
T1716	Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neu...
TL0006	Cichoric Acid	6537-80-0	98.57%
TL0006	Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a ...
T63016	Nrf2 activator-4	2383016-68-8	98.53%
T63016	Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated wi...
T0223	Tetrahydroxyquinone	319-89-1	98.47%
T0223	Tetrahydroxyquinone (Tetroquinone) is a molecule best known as a primitive anticataract drug, is also a highly redox active molecule that can take part in a redo...
T2864	Lycopene	502-65-8	98.47%
T2864	Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges...
T38310	Luciferase-IN-1	10205-56-8	98.43%
T38310	Luciferase-IN-1 is a luciferase inhibitor that can be used to study bacterial and fungal infections.
T8193	α-Thujone	546-80-5	98.41%
T8193	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T2871	Quercitrin	522-12-3	98.4%
T2871	Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a num...
T5363	Tempo	2564-83-2	98.35%
T5363	Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a stru...
T16747	Riboflavin Tetrabutyrate	752-56-7	98.34%
T16747	Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.
T11580	Heme Oxygenase-1-IN-1	1093058-52-6	98.26%
T11580	Heme Oxygenase-1-IN-1 (HO-1-IN-1) is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).
T5030	Zofenopril calcium	81938-43-4	98.25%
T5030	Zofenopril calcium (SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. ACE Zofenopril is a pro-drug designed to undergo metaboli...
T4172	Methoxy-PMS	65162-13-2	98.25%
T4172	Methoxy-PMS (1-Methoxyphenazine methosulfate) is stable electron-transport mediator between NAD(P)H and tetrazolium dyes, can induce active oxygen formation.