Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No.	Product name	CAS No.	Purity
T10668	Camalexin	135531-86-1	98%
T10668	Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce RO...
T1439	Lacidipine	103890-78-4	98%
T1439	Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does n...
T3604	Sodium dichloroacetate	2156-56-1	98%
T3604	Dichloroacetate, a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to ...
TN1141	Isodeoxyelephantopin	38927-54-7	98%
TN1141	Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
T0933	D-(+)-Glucono-1,5-lactone	90-80-2	98%
T0933	Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-g...
T2796	Coenzyme Q10	303-98-0	98%
T2796	Coenzyme Q10 (ubiquinone) is a naturally occurring compound, acting as the electron carrier in the mitochondrial respiratory chain.
T1648	α-Vitamin E	59-02-9	98%
T1648	(+)-α-Tocopherol is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
T0928	L-Ascorbic acid	50-81-7	98%
T0928	Vitamin C is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen....
T6947	Piperlongumine	20069-09-4	98%
T6947	Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T2597	Norgestrel	6533-00-2	98%
T2597	Norgestrel is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing ...
T3753	Sinapinic Acid	530-59-6	98%
T3753	Sinapic acid protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and p...
T9057	Norbergenin	79595-97-4	98%
T9057	Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
T0875	Acetylcysteine	616-91-1	98%
T0875	Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
TN1674	Garcinone D	107390-08-9	98%
TN1674	Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
T2220	2-Methoxyestradiol	362-07-2	98%
T2220	2-Methoxyestradiol is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing en...
T3744	Veratric acid	93-07-2	98%
T3744	Veratric acid is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects.
T0877	Gallic acid	149-91-7	98%
T0877	Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T4287	Succinobucol	216167-82-7	98%
T4287	Succinobucol is a novel phenolic antioxidant small molecule with anti-oxidant and anti-inflammatory properties. It designed to treat atherosclerosis of the blood...
T3730	Methyl gallate	99-24-1	98%
T3730	Methyl gallate is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
T3332	Isosteviol	27975-19-5	98%
T3332	Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysi...