Syk

Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.

Cat. No.	Product name	CAS No.	Purity
T11824	Lanraplenib succinate	1800047-00-0	98%
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanr...
TN7075	Linocinnamarin	554-87-0	98%
Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
T6003	GSK1904529A	1089283-49-7	98%
GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T6104	Cerdulatinib hydrochloride	1369761-01-2	98%
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
TN1549	Damnacanthal	477-84-9	98%
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
T11824L	Lanraplenib monosuccinate	1800046-97-2	98%
Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. ...
T16995	TAS05567	1429038-15-2	98%
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
T9789	Cevidoplenib dimesylate hydrochloride	269062-93-3	98%
Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.
T16776	RO9021	1446790-62-0	98%
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
T22430	SRX3207	2254693-15-5	98%
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
T6957	PRT-060318	1194961-19-7	98%
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
T2605	Fostamatinib Disodium	1025687-58-4	96.13%
Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.
T39437	Cevidoplenib dimesylate	2043659-93-2	96.16%
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
T6115	Fostamatinib	901119-35-5	98.3%
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T6594	MNS	1485-00-3	98.45%
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
T4263	BAY 61-3606	732983-37-8	98.72%
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effec...
T6174	R406	841290-81-1	98.82%
R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
T2467	R406 free base	841290-80-0	99.31%
R406 (free base) is a potent Syk inhibitor.
T6057	URMC-099	1229582-33-5	99.32%
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T0610	Piceatannol	10083-24-6	99.39%
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T11824

Lanraplenib succinate

1800047-00-0

98%

Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanr...

TN7075

Linocinnamarin

554-87-0

98%

Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...

T6003

GSK1904529A

1089283-49-7

98%

GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .

T6104

Cerdulatinib hydrochloride

1369761-01-2

98%

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...

TN1549

Damnacanthal

477-84-9

98%

Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...

T11824L

Lanraplenib monosuccinate

1800046-97-2

98%

Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. ...

T16995

TAS05567

1429038-15-2

98%

TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...

T9789

Cevidoplenib dimesylate hydrochloride

269062-93-3

98%

Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.

T16776

RO9021

1446790-62-0

98%

RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).

T22430

SRX3207

2254693-15-5

98%

SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.

T6957

PRT-060318

1194961-19-7

98%

PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.

T2605

Fostamatinib Disodium

1025687-58-4

96.13%

Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.

T39437

Cevidoplenib dimesylate

2043659-93-2

96.16%

Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.

T6115

Fostamatinib

901119-35-5

98.3%

Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.

T6594

MNS

1485-00-3

98.45%

MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.

T4263

BAY 61-3606

732983-37-8

98.72%

BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effec...

T6174

R406

841290-81-1

98.82%

R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.

T2467

R406 free base

841290-80-0

99.31%

R406 (free base) is a potent Syk inhibitor.

T6057

URMC-099

1229582-33-5

99.32%

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...

T0610

Piceatannol

10083-24-6

99.39%

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...