T11824 |
Lanraplenib succinate
|
1800047-00-0
|
98%
|
|
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanr...
|
TN7075 |
Linocinnamarin
|
554-87-0
|
98%
|
|
Linocinnamarin is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of S...
|
T6003 |
GSK1904529A
|
1089283-49-7
|
98%
|
|
GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
|
T6104 |
Cerdulatinib hydrochloride
|
1369761-01-2
|
98%
|
|
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
|
TN1549 |
Damnacanthal
|
477-84-9
|
98%
|
|
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
|
T11824L |
Lanraplenib monosuccinate
|
1800046-97-2
|
98%
|
|
Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. ...
|
T16995 |
TAS05567
|
1429038-15-2
|
98%
|
|
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
|
T9789 |
Cevidoplenib dimesylate hydrochloride
|
269062-93-3
|
98%
|
|
Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.
|
T16776 |
RO9021
|
1446790-62-0
|
98%
|
|
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
|
T22430 |
SRX3207
|
2254693-15-5
|
98%
|
|
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
|
T6957 |
PRT-060318
|
1194961-19-7
|
98%
|
|
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
|
T2605 |
Fostamatinib Disodium
|
1025687-58-4
|
96.13%
|
|
Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.
|
T39437 |
Cevidoplenib dimesylate
|
2043659-93-2
|
96.16%
|
|
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
|
T6115 |
Fostamatinib
|
901119-35-5
|
98.3%
|
|
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
|
T6594 |
MNS
|
1485-00-3
|
98.45%
|
|
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
|
T4263 |
BAY 61-3606
|
732983-37-8
|
98.72%
|
|
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effec...
|
T6174 |
R406
|
841290-81-1
|
98.82%
|
|
R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
|
T2467 |
R406 free base
|
841290-80-0
|
99.31%
|
|
R406 (free base) is a potent Syk inhibitor.
|
T6057 |
URMC-099
|
1229582-33-5
|
99.32%
|
|
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
|
T0610 |
Piceatannol
|
10083-24-6
|
99.39%
|
|
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...
|