TAM Receptor

The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine kinases,Their regulatory roles are prominent in the mature immune, reproductive, hematopoietic, vascular, and nervous systems. The TAMs and their ligands—Gas6 and Protein S—are essential for the efficient phagocytosis of apoptotic cells and membranes in these tissues.

Cat. No.	Product name	CAS No.	Purity
T2311	LDC1267	1361030-48-9	99.42%
T2311	LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).
T73300	AXL-IN-13	2376928-82-2	99.38%
T73300	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
T21302	UNC569	1350547-65-7	99.31%
T21302	UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric aci...
T9123	DS-1205	1855860-24-0	99.28%
T9123	DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, r...
T2699	BMS 777607	1025720-94-8	99.22%
T2699	BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3 (IC50: 3.9/1.1/1.8/4.3 nM). BMS-777607 has been investigated for the basic science of ...
T4349	Sitravatinib	1123837-84-2	98.9%
T4349	Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Ax...
T1797	Cabozantinib S-malate	1140909-48-3	98.87%
T1797	Cabozantinib S-malate (XL184) is the s-malate salt form of cabozantinib, an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with pot...
T2005	Dubermatinib	1341200-45-0	98.65%
T2005	Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.
T6121	Tepotinib	1100598-32-0	98.35%
T6121	Tepotinib (EMD-1214063) is an inhibitor of MET tyrosine kinase with potential antineoplastic activity.
T8327	ONO-7475	1646839-59-9	98.33%
T8327	ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
T2620	G-749	1457983-28-6	98.32%
T2620	G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
T6120	Pralatrexate	146464-95-1	98.12%
T6120	Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carr...
T71973	Gilteritinib hemifumarate	1254053-84-3	98.07%
T71973	Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of rel...
T6269	Bemcentinib	1037624-75-1	98%
T6269	Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
T7379	2-D08	144707-18-6	98%
T7379	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
T6907	NPS-1034	1221713-92-3	97.86%
T6907	NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.
T3274	S49076	1265965-22-7	97.4%
T3274	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
T5164	Cabozantinib hydrochloride	1817759-42-4	97.09%
T5164	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM...
T21302L	UNC 569 hydrochloride		100%
T21302L	UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro...
T21302L	UNC 569 hydrochloride		100%
T21302L	UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro...