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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2197 Secoisolariciresinol 29388-59-8 98%
Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation...
T12997 SR-318 2413286-32-3 98%
SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti...
TN1731 Hernandezine 6681-13-6 98%
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
T2758 Madecassic acid 18449-41-7 98%
Madecassic acid is extracted from the whole herb of Centella asiatica.
T4S0217 HOMOPLANTAGININ 17680-84-1 98%
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
T6S0630 Hypaconitine 6900-87-4 98%
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T4412 Roquinimex 84088-42-6 98%
Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces t...
T13951 UCB-9260 1515888-53-5 98%
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
T2720 Ginsenoside Rc 11021-14-0 98%
Ginsenoside Rc is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β.
T4S0998 Trifolirhizin 6807-83-6 98%
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirh...
TQ0218 Deoxyandrographolide 79233-15-1 98%
Deoxyandrographolide (14-deoxyandrographolide) has an antihyperglycemic effect in vivo. It also potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile...
T2367 SKF-86002 72873-74-6 98%
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
TN1507 Clematichinenoside AR 761425-93-8 98%
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associate...
T0429 Glucosamine 3416-24-8 98%
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T7001 TIC10 1616632-77-9 98%
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and...
T5S0993 Kurarinone 34981-26-5 98%
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
TN1936 Mogroside III-E 88901-37-5 98%
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
T6S1538 Neochlorogenic acid 906-33-2 98%
(E)-Neochlorogenic Acid is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
TN1742 Homovanillyl alcohol 2380-78-1 98%
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
T2S0501 Ilexgenin A 108524-94-3 98%
Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr
Secoisolariciresinol
TN2197
Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation...
SR-318
T12997
SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti...
Hernandezine
TN1731
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
Madecassic acid
T2758
Madecassic acid is extracted from the whole herb of Centella asiatica.
HOMOPLANTAGININ
T4S0217
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
Hypaconitine
T6S0630
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
Roquinimex
T4412
Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces t...
UCB-9260
T13951
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
Ginsenoside Rc
T2720
Ginsenoside Rc is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β.
Trifolirhizin
T4S0998
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirh...
Deoxyandrographolide
TQ0218
Deoxyandrographolide (14-deoxyandrographolide) has an antihyperglycemic effect in vivo. It also potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile...
SKF-86002
T2367
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
Clematichinenoside AR
TN1507
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associate...
Glucosamine
T0429
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
TIC10
T7001
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and...
Kurarinone
T5S0993
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
Mogroside III-E
TN1936
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
Neochlorogenic acid
T6S1538
(E)-Neochlorogenic Acid is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
Homovanillyl alcohol
TN1742
Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
Ilexgenin A
T2S0501
Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr
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