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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Cat. No. Product name CAS No. Purity Chemical Structure
T2794 Astilbin 29838-67-3 98%
Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T2932 Ginsenoside Rh1 63223-86-9 98%
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
TN2079 (-)-Pinoresinol 81446-29-9 98%
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
T3770 Taraxasterol 1059-14-9 98%
Taraxasterol is compound with anti-inflammatory activity.
T2065 Bioymifi 1420071-30-2 98%
Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
TN1295 5-O-Caffeoylshikimic acid 73263-62-4 98%
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
TN3609 Catalposide 6736-85-2 98%
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
T5S1632 Barlerin 57420-46-9 98%
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
T5788 XYLOBIOSE 6860-47-5 98%
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metaboli...
T0694 Pranlukast 103177-37-3 98%
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
T2A2481 Taurochenodeoxycholic Acid 516-35-8 98%
Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T1265 Amrinone 60719-84-8 98%
Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
T1813 VGX-1027 6501-72-0 98%
VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
T6204 QNZ 545380-34-5 98%
QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
T4450 GIBH-130 1252608-59-5 98%
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
T0213 Thalidomide 50-35-1 98%
Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic ...
T0304 Methylthiouracil 56-04-2 98%
Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T61111 UCB-5307 1515887-44-1 98%
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directl...
T4403 AX-024 hydrochloride 1704801-24-0 98%
AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interfer...
T1125 Shikonin 517-89-5 98%
Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...
Astilbin
T2794
Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
Ginsenoside Rh1
T2932
Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
(-)-Pinoresinol
TN2079
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
Taraxasterol
T3770
Taraxasterol is compound with anti-inflammatory activity.
Bioymifi
T2065
Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
5-O-Caffeoylshikimic acid
TN1295
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
Catalposide
TN3609
Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
Barlerin
T5S1632
8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
XYLOBIOSE
T5788
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metaboli...
Pranlukast
T0694
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
Taurochenodeoxycholic Acid
T2A2481
Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
Amrinone
T1265
Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
VGX-1027
T1813
VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
QNZ
T6204
QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
GIBH-130
T4450
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
Thalidomide
T0213
Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic ...
Methylthiouracil
T0304
Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
UCB-5307
T61111
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directl...
AX-024 hydrochloride
T4403
AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interfer...
Shikonin
T1125
Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...
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