TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
T2794	Astilbin	29838-67-3	98%
T2794	Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T2932	Ginsenoside Rh1	63223-86-9	98%
T2932	Ginsenoside Rg1, one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
TN2079	(-)-Pinoresinol	81446-29-9	98%
TN2079	(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
T3770	Taraxasterol	1059-14-9	98%
T3770	Taraxasterol is compound with anti-inflammatory activity.
T2065	Bioymifi	1420071-30-2	98%
T2065	Bioymifi is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.
TN1295	5-O-Caffeoylshikimic acid	73263-62-4	98%
TN1295	5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of...
TN3609	Catalposide	6736-85-2	98%
TN3609	Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, a...
T5S1632	Barlerin	57420-46-9	98%
T5S1632	8-O-Acetylshanzhiside methylester has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be...
T5788	XYLOBIOSE	6860-47-5	98%
T5788	XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metaboli...
T0694	Pranlukast	103177-37-3	98%
T0694	Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
T2A2481	Taurochenodeoxycholic Acid	516-35-8	98%
T2A2481	Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T1265	Amrinone	60719-84-8	98%
T1265	Amrinone is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
T1813	VGX-1027	6501-72-0	98%
T1813	VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
T6204	QNZ	545380-34-5	98%
T6204	QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
T4450	GIBH-130	1252608-59-5	98%
T4450	GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
T0213	Thalidomide	50-35-1	98%
T0213	Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic ...
T0304	Methylthiouracil	56-04-2	98%
T0304	Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T61111	UCB-5307	1515887-44-1	98%
T61111	UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directl...
T4403	AX-024 hydrochloride	1704801-24-0	98%
T4403	AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interfer...
T1125	Shikonin	517-89-5	98%
T1125	Shikonin is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of the NF-κB pathw...