TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TN1983	Neoisoastilbin	54141-72-9	100%
TN1983	Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T0304	Methylthiouracil	56-04-2	100%
T0304	Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T36524	IKK2-IN-4	354811-10-2	100%
T36524	IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
T5785	MALTOTETRAOSE	34612-38-9
T5785	Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in th...
T3426	Bacoside A	11028-00-5
T3426	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotect...
T3280	Clodronate disodium tetrahydrate	88416-50-6
T3280	Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.
T0213	Thalidomide	50-35-1
T0213	Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-...
T2893	Muscone	541-91-3
T2893	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T3123	Allicin	539-86-6
T3123	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cel...
T3790	Hederacoside D	760961-03-3
T3790	Hederacoside D is a bioactive saponins from Hedera helix.
TQ0218	Deoxyandrographolide	79233-15-1	98%
TQ0218	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory media...
TN4583	Moringin	73255-40-0	98%
TN4583	Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T12985	SPD304 dihydrochloride	1049741-03-8	98%
T12985	SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.
TN1599	Eburicoic acid	560-66-7	98%
TN1599	Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in...
TC0036	Compound Lup-20(29)-en-3-yl acetate	TC0036	98%
TC0036	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
TN1403	Arjunolic acid	465-00-9	98%
TN1403	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
TN2539	1beta-Hydroxyalantolactone	68776-47-6	98%
TN2539	1beta-Hydroxyalantolactone is a small molecular compound isolated from the flower head of the medicinal plant giant British flower, which can inhibit the express...
TN7235	4-methoxylonchocarpin	51589-67-4	98%
TN7235	4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TN...
T14848	C 87	332420-90-3	98%
T14848	C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-...
T76705	Utomilumab	1417318-27-4	98%
T76705	Utomilumab (PF 05082566) is a humanized IgG2 antibody targeting the T-cell co-stimulatory receptor 4-1BB/CD137 and a 4-1BB/CD137 agonist.Utomilumab has antitumor...