TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TN1599	Eburicoic acid	560-66-7	98%
TN1599	Eburicoic acid exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about...
TC0036	Compound Lup-20(29)-en-3-yl acetate	TC0036	98%
TC0036	Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.
TN1403	Arjunolic acid	465-00-9	98%
TN1403	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
TN7235	4-methoxylonchocarpin	51589-67-4	98%
TN7235	4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TN...
T14848	C 87	332420-90-3	98%
T14848	C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-...
T76830	Teneliximab	299423-37-3	98%
T76830	Teneliximab is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Tene...
T76957	Belimumab	356547-88-1	98%
T76957	Belimumab(LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits B-cell activating factor (BAFF).Belimumab is used in the study of fatigue and in the t...
T77494	TNF-α-IN-9	2054199-25-4	98%
T77494	TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.
T9921	Infliximab	170277-31-3	98%
T9921	Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.
T14381	AZD7624	1095004-78-6	98%
T14381	AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.
T1813	VGX-1027	6501-72-0	98%
T1813	VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties.
T5S0993	Kurarinone	34981-26-5	98%
T5S0993	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T26326	VU0285655-1	1158347-73-9	98%
T26326	VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhib...
TN2079	(-)-Pinoresinol	81446-29-9	98%
TN2079	(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
TN1936	Mogroside III-E	88901-37-5	98%
TN1936	Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
TN1475	Caulophyllogenin	52936-64-8	98%
TN1475	Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammat...
T0213	Thalidomide	50-35-1	98%
T0213	Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic ...
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
TN1660	Ganoderic acid C1	95311-97-0	98%
TN1660	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
TQ0181	Resatorvid	243984-11-4	98%
TQ0181	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...