TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TN4374	Kaerophyllin	75590-33-9	98%
TN4374	Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
TN1359	Aflatoxin G1	1165-39-5	98%
TN1359	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
TN1242	3,3'-Di-O-methylellagic acid	2239-88-5	98%
TN1242	3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a ...
TN5264	Xanthoxyletin	84-99-1	98%
TN5264	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
T16755	RIPK-IN-4	2141969-56-2	98%
T16755	RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).
T14312	Apratastat	287405-51-0	98%
T14312	Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) an...
TN3245	7-O-Methylmorroniside	119943-46-3	98%
TN3245	7-O-Methylmorroniside exhibits anti-inflammatory activity.
T5768	Bruceine B	25514-29-8	98%
T5768	Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysacchar...
TMA0627	Taxiresinol	40951-69-7	98%
TMA0627	Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
TN4648	Nepetoidin B	55486-06-1	98%
TN4648	Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated ...
TN1960	Mussaenoside	64421-27-8	98%
TN1960	Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN4581	Moracin D	69120-07-6	98%
TN4581	Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
TN3692	Conduritol A	526-87-4	98%
TN3692	Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant abilit...
T13175	TNF-α-IN-1	444287-49-4	98%
T13175	TNF-α-IN-1 is a TNF-α inhibitor, information extracted from Patent US20030096841A1 in Compound Examples I-7.
TN4162	Goshonoside F5	90851-28-8	98%
TN4162	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TMA2576	Episappanol	111254-18-3	98%
TMA2576	Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis f...
TN4334	Isotaxiresinol	26194-57-0	98%
TN4334	Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activa...
T2434	LY 303511	154447-38-8	98%
T2434	LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.
TN1354	Aaptamine	85547-22-4	98%
TN1354	Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
TN4194	Heliangin	13323-48-3	98%
TN4194	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells...