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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Cat. No. Product name CAS No. Purity Chemical Structure
TN4986 Selinidin 19427-82-8 98%
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
T12985L SPD304 869998-49-2 98%
SPD304 is a selective TNF-α inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 bind...
TN4093 Galeopsin 76475-16-6 98%
Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines....
TN2178 Sanggenone H 86450-80-8 98%
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated m...
TN4190 Hedycoronen A 1383441-73-3 98%
Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, w...
TN4776 Physalin D 54980-22-2 98%
Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 m...
TN4392 Koaburaside 41653-73-0 98%
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have ...
TN2149 Reynosin 28254-53-7 98%
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
TN5912 Macluraxanthone 5848-14-6 98%
Macluraxanthone has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effect...
TN2588 11-Hydroxytephrosin 72458-85-6 98%
11-Hydroxytephrosin inhibits NF-kappaB activity.
TN1212 2-Hydroxyeupatolide 72229-33-5 98%
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and m...
TN3495 Benzyl ferulate 132335-97-8 98%
Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE...
TN4064 Flavoglaucin 523-73-9 98%
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TMA1409 Cis-Mulberroside A 166734-06-1 98%
cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
TN5238 Viscidulin II 92519-93-2 98%
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β produ...
TN4303 Isokaempferide 1592-70-7 98%
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
TN3453 Arteannuin N 207446-92-2 98%
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 113981-49-0 98%
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
TN1232 5,7-Dimethoxyflavanone 1277188-85-8 98%
5,7-Dimethoxyflavanone has anti-inflammatory activity.
T11474 GSK-843 1601496-05-2 98%
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor ( IC50: 8.6 nM for binding RIP3 kinase domain; IC50: 6.5 nM for inhibiting kinase ac...
Selinidin
TN4986
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
SPD304
T12985L
SPD304 is a selective TNF-α inhibitor and blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 bind...
Galeopsin
TN4093
Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines....
Sanggenone H
TN2178
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated m...
Hedycoronen A
TN4190
Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, w...
Physalin D
TN4776
Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 m...
Koaburaside
TN4392
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have ...
Reynosin
TN2149
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
Macluraxanthone
TN5912
Macluraxanthone has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effect...
11-Hydroxytephrosin
TN2588
11-Hydroxytephrosin inhibits NF-kappaB activity.
2-Hydroxyeupatolide
TN1212
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and m...
Benzyl ferulate
TN3495
Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE...
Flavoglaucin
TN4064
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
cis-Mulberroside A
TMA1409
cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
Viscidulin II
TN5238
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β produ...
Isokaempferide
TN4303
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
Arteannuin N
TN3453
Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
5-Hydroxy-7,8-dimethoxyflavanone
TN3119
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
5,7-Dimethoxyflavanone
TN1232
5,7-Dimethoxyflavanone has anti-inflammatory activity.
GSK-843
T11474
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor ( IC50: 8.6 nM for binding RIP3 kinase domain; IC50: 6.5 nM for inhibiting kinase ac...
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