TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TN2895	3,5-Dicaffeoyl-epi-quinic acid	879305-14-3	98%
TN2895	3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
T4S1057	Tripdiolide	38647-10-8	98%
T4S1057	Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.
TN3541	Broussonin E	90902-21-9	98%
TN3541	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
TN3655	Cimiside E	154822-57-8	98%
TN3655	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
TN4013	Esculentic acid	103974-74-9	98%
TN4013	Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the ...
T10350	Apremilast-d5	1258597-47-5	98%
T10350	Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α rele...
TN3806	Dehydroglyasperin C	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN4418	Lasiodiplodin	32885-81-7	98%
TN4418	Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron tran...
TN4635	Neoechinulin A	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
T6591	Nodinitib-1	799264-47-4	99.98%
T6591	Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T8845	UTL-5g	646530-37-2	99.97%
T8845	UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side...
T3332	Isosteviol	27975-19-5	99.97%
T3332	Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside ...
T2205	Acefylline	652-37-9	99.95%
T2205	Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhyd...
T9057	Norbergenin	79595-97-4	99.93%
T9057	Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.
TN1933	Mitraphylline	509-80-8	99.93%
TN1933	Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-...
T6S2099	Geraniin	60976-49-0	99.92%
T6S2099	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Gerani...
T2S0843	Negletein	29550-13-8	99.92%
T2S0843	1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotecta...
T4403	AX-024 hydrochloride	1704801-24-0	99.9%
T4403	AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TN...
T4450	GIBH-130	1252608-59-5	99.86%
T4450	GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation.
T6204	QNZ	545380-34-5	99.86%
T6204	QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.