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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Cat. No. Product name CAS No. Purity Chemical Structure
TQ0181 Resatorvid 243984-11-4 98%
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
T2993 Cordycepin 73-03-0 98%
Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
TN1983 Neoisoastilbin 54141-72-9 98%
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T11484 GSK2593074A 1337531-06-2 98%
GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T22922 Lenalidomide hemihydrate 847871-99-2 98%
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
T7889 C25-140 1358099-18-9 98%
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
TN1511 Cleomiscosin A 76948-72-6 98%
Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin ...
TN3849 Dihydrodehydrodiconiferyl alcohol 28199-69-1 98%
Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
T4423 LY 303511 hydrochloride 2070014-90-1 98%
LY303511 (NV-128)is a potent mTOR inhibitor
T6S2140 β-Anhydroicaritin 38226-86-7 98%
1. Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. Anhydroicaritin phytosomes can inhibit enhanced bone turnover...
TN1373 α-Humulene 6753-98-6 98%
Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects,...
T5S0167 Atractylenolide I 73069-13-3 98%
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T60054 EJMC-1 397281-20-8 98%
EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.
T2S0731 Trilobatin 4192-90-9 98%
Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopol...
T6S0653 Linarin 480-36-4 98%
1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver i...
TN1803 Isoscoparin 20013-23-4 98%
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
T5660 Menthone 10458-14-7 98%
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
T5779 MOSLOFLAVONE 740-33-0 98%
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
T3S0006 (E)-Ferulic acid methyl ester 22329-76-6 98%
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first ...
T10865L Cot inhibitor-1 hydrochloride T10865L 98%
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...
Resatorvid
TQ0181
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
Cordycepin
T2993
Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
Neoisoastilbin
TN1983
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
GSK2593074A
T11484
GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
Lenalidomide hemihydrate
T22922
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
C25-140
T7889
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
Cleomiscosin A
TN1511
Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin ...
Dihydrodehydrodiconiferyl alcohol
TN3849
Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
LY 303511 hydrochloride
T4423
LY303511 (NV-128)is a potent mTOR inhibitor
β-Anhydroicaritin
T6S2140
1. Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. Anhydroicaritin phytosomes can inhibit enhanced bone turnover...
α-Humulene
TN1373
Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects,...
Atractylenolide I
T5S0167
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
EJMC-1
T60054
EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.
Trilobatin
T2S0731
Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopol...
Linarin
T6S0653
1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver i...
Isoscoparin
TN1803
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
Menthone
T5660
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
MOSLOFLAVONE
T5779
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
(E)-Ferulic acid methyl ester
T3S0006
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first ...
Cot inhibitor-1 hydrochloride
T10865L
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...
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