TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TQ0181	Resatorvid	243984-11-4	98%
TQ0181	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
T2993	Cordycepin	73-03-0	98%
T2993	Cordycepin is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.
TN1983	Neoisoastilbin	54141-72-9	98%
TN1983	Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T11484	GSK2593074A	1337531-06-2	98%
T11484	GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T22922	Lenalidomide hemihydrate	847871-99-2	98%
T22922	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
T7889	C25-140	1358099-18-9	98%
T7889	C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
TN1511	Cleomiscosin A	76948-72-6	98%
TN1511	Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin ...
TN3849	Dihydrodehydrodiconiferyl alcohol	28199-69-1	98%
TN3849	Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
T4423	LY 303511 hydrochloride	2070014-90-1	98%
T4423	LY303511 (NV-128)is a potent mTOR inhibitor
T6S2140	β-Anhydroicaritin	38226-86-7	98%
T6S2140	1. Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. Anhydroicaritin phytosomes can inhibit enhanced bone turnover...
TN1373	α-Humulene	6753-98-6	98%
TN1373	Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects,...
T5S0167	Atractylenolide I	73069-13-3	98%
T5S0167	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T60054	EJMC-1	397281-20-8	98%
T60054	EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.
T2S0731	Trilobatin	4192-90-9	98%
T2S0731	Trilobatin has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopol...
T6S0653	Linarin	480-36-4	98%
T6S0653	1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver i...
TN1803	Isoscoparin	20013-23-4	98%
TN1803	Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
T5660	Menthone	10458-14-7	98%
T5660	Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
T5779	MOSLOFLAVONE	740-33-0	98%
T5779	MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
T3S0006	(E)-Ferulic acid methyl ester	22329-76-6	98%
T3S0006	Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first ...
T10865L	Cot inhibitor-1 hydrochloride	T10865L	98%
T10865L	Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...