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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6S0630 Hypaconitine 6900-87-4 99.63%
Hypaconitine
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T4S0217 HOMOPLANTAGININ 17680-84-1 99.6%
HOMOPLANTAGININ
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
TN2259 Taurocholic acid 81-24-3 99.59%
Taurocholic acid
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-al...
T2758 Madecassic acid 18449-41-7 99.55%
Madecassic acid
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.
TN1731 Hernandezine 6681-13-6 99.53%
Hernandezine
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
T12997 SR-318 2413286-32-3 99.53%
SR-318
SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti...
T1642 Lenalidomide 191732-72-6 99.52%
Lenalidomide
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
TN2197 Secoisolariciresinol 29388-59-8 99.51%
Secoisolariciresinol
Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation...
TN1362 Afzelin 482-39-3 99.38%
Afzelin
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absor...
TN2082 Pinostrobin 480-37-5 99.35%
Pinostrobin
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
T4S0998 Trifolirhizin 6807-83-6 99.27%
Trifolirhizin
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirh...
TN1996 Nothofagin 11023-94-2 99.21%
Nothofagin
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
T13824 PP58 212391-58-7 99.21%
PP58
PP58 is an inhibitor of PDGFR, FGFR and Src family.
T10865 Cot inhibitor-1 915365-57-0 99.19%
Cot inhibitor-1
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in ...
T5S2129 Sciadopitysin 521-34-6 99.17%
Sciadopitysin
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
T6204 QNZ 545380-34-5 99.17%
QNZ
QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
T2794 Astilbin 29838-67-3 99.13%
Astilbin
Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T6S1597 Mulberroside A 102841-42-9 99.05%
Mulberroside A
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosy...
TN2064 Physcion 8-O-β-D-glucopyranoside 23451-01-6 99.04%
Physcion 8-O-β-D-glucopyranoside
Physcion 8-O-β-D-glucopyranoside (Physcion 8-O-beta-D-monoglucoside) has anti-inflammatory and anti-cancer activities. Physcion 8-O-β-D-glucopyranoside can be us...
T0122 Bergenin 477-90-7 99.01%
Bergenin
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Hypaconitine
T6S0630
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
HOMOPLANTAGININ
T4S0217
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
Taurocholic acid
TN2259
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-al...
Madecassic acid
T2758
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.
Hernandezine
TN1731
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
SR-318
T12997
SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti...
Lenalidomide
T1642
Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
Secoisolariciresinol
TN2197
Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation...
Afzelin
TN1362
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absor...
Pinostrobin
TN2082
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
Trifolirhizin
T4S0998
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirh...
Nothofagin
TN1996
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
PP58
T13824
PP58 is an inhibitor of PDGFR, FGFR and Src family.
Cot inhibitor-1
T10865
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in ...
Sciadopitysin
T5S2129
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
QNZ
T6204
QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
Astilbin
T2794
Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
Mulberroside A
T6S1597
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosy...
Physcion 8-O-β-D-glucopyranoside
TN2064
Physcion 8-O-β-D-glucopyranoside (Physcion 8-O-beta-D-monoglucoside) has anti-inflammatory and anti-cancer activities. Physcion 8-O-β-D-glucopyranoside can be us...
Bergenin
T0122
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
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TargetMol