TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
T2794	Astilbin	29838-67-3	98%
T2794	Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T0131	Cepharanthine	481-49-2	98%
T0131	Cepharanthine, a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggr...
TN1742	Homovanillyl alcohol	2380-78-1	98%
TN1742	Homovanillyl alcohol is a biological metabolite of Hydroxytyrosol. Hydroxytyrosol is a phenolic compound that is present in virgin olive oil (VOO) and wine. Homo...
T6S1538	Neochlorogenic acid	906-33-2	98%
T6S1538	(E)-Neochlorogenic Acid is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
T7001	TIC10	1616632-77-9	98%
T7001	TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and...
T0429	Glucosamine	3416-24-8	98%
T0429	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T2A2481	Taurochenodeoxycholic Acid	516-35-8	98%
T2A2481	Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
T2720	Ginsenoside Rc	11021-14-0	98%
T2720	Ginsenoside Rc is one of the ginsenosides from Panax ginseng, inhibits the expression of TNF-α and IL-1β.
T13951	UCB-9260	1515888-53-5	98%
T13951	UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
T4412	Roquinimex	84088-42-6	98%
T4412	Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces t...
T6S0630	Hypaconitine	6900-87-4	98%
T6S0630	Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T3805	Prim-O-glucosylcimifugin	80681-45-4	98%
T3805	Prim-O-glucosylcimifugin can inhibit the proliferation of SMC(smooth muscle cell) stimulated by TNF-alpha, increase the proportion of G0/G1 phase.
TN1731	Hernandezine	6681-13-6	98%
TN1731	Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
T12997	SR-318	2413286-32-3	98%
T12997	SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti...
T1642	Lenalidomide	191732-72-6	98%
T1642	Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
TN2197	Secoisolariciresinol	29388-59-8	98%
TN2197	Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation...
T2758	Madecassic acid	18449-41-7	98%
T2758	Madecassic acid is extracted from the whole herb of Centella asiatica.
TN1362	Afzelin	482-39-3	98%
TN1362	Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protec...
TN2082	Pinostrobin	480-37-5	98%
TN2082	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
T4S0998	Trifolirhizin	6807-83-6	98%
T4S0998	Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirh...