Home Tools
Log in
Cart

TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN1996 Nothofagin 11023-94-2 99.21%
Nothofagin
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
T13824 PP58 212391-58-7 99.21%
PP58
PP58 is an inhibitor of PDGFR, FGFR and Src family.
T10865 Cot inhibitor-1 915365-57-0 99.19%
Cot inhibitor-1
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in ...
T5S2129 Sciadopitysin 521-34-6 99.17%
Sciadopitysin
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
T6S1597 Mulberroside A 102841-42-9 99.05%
Mulberroside A
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosy...
TN2064 Physcion 8-O-β-D-glucopyranoside 23451-01-6 99.04%
Physcion 8-O-β-D-glucopyranoside
Physcion 8-O-β-D-glucopyranoside (Physcion 8-O-beta-D-monoglucoside) has anti-inflammatory and anti-cancer activities. Physcion 8-O-β-D-glucopyranoside can be us...
T0122 Bergenin 477-90-7 99.01%
Bergenin
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T0875 Acetylcysteine 616-91-1 98.98%
Acetylcysteine
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
T6S0627 Mesaconitine 2752-64-9 98.98%
Mesaconitine
1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system...
T4637 R-7050 303997-35-5 98.95%
R-7050
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.
T2S2264 Linalool 78-70-6 98.95%
Linalool
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
T4S0227 Sinensetin 2306-27-6 98.93%
Sinensetin
Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin e...
T60657 (R)-STU104 2767124-77-4 98.91%
(R)-STU104
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathwa...
T1738 Taxifolin 480-18-2 98.9%
Taxifolin
Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
T3S1641 Esculentoside H 66656-92-6 98.9%
Esculentoside H
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
T2367 SKF-86002 72873-74-6 98.89%
SKF-86002
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
T10866 Cot inhibitor-2 915363-56-3 98.87%
Cot inhibitor-2
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α produc...
T29857 Alethine 646-08-2 98.82%
Alethine
Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TN...
T10730 CDC801 192819-27-5 98.81%
CDC801
CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.
T2384 Pomalidomide 19171-19-8 98.8%
Pomalidomide
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
Nothofagin
TN1996
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
PP58
T13824
PP58 is an inhibitor of PDGFR, FGFR and Src family.
Cot inhibitor-1
T10865
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in ...
Sciadopitysin
T5S2129
Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin sh...
Mulberroside A
T6S1597
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosy...
Physcion 8-O-β-D-glucopyranoside
TN2064
Physcion 8-O-β-D-glucopyranoside (Physcion 8-O-beta-D-monoglucoside) has anti-inflammatory and anti-cancer activities. Physcion 8-O-β-D-glucopyranoside can be us...
Bergenin
T0122
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Acetylcysteine
T0875
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
Mesaconitine
T6S0627
1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system...
R-7050
T4637
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.
Linalool
T2S2264
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
Sinensetin
T4S0227
Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin e...
(R)-STU104
T60657
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathwa...
Taxifolin
T1738
Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
Esculentoside H
T3S1641
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
SKF-86002
T2367
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
Cot inhibitor-2
T10866
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α produc...
Alethine
T29857
Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TN...
CDC801
T10730
CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.
Pomalidomide
T2384
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
1 2 3 4 5 6 7 8 9 10 11 12 13
TargetMol