T4952 |
9-Hydroxycamptothecin
|
67656-30-8
|
99.79%
|
|
9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.
|
T13231 |
Trovafloxacin
|
147059-72-1
|
99.27%
|
|
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
|
T14545 |
Berberine chloride hydrate
|
68030-18-2
|
98.94%
|
|
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, ...
|
TN2105 |
Proscillaridin A
|
466-06-8
|
98.38%
|
|
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
|
T6724 |
Voreloxin
|
175414-77-4
|
98%
|
|
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
|
T11090L |
Aldoxorubicin
|
1361644-26-9
|
98%
|
|
Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
|
T16726 |
Rebeccamycin
|
93908-02-2
|
98%
|
|
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
|
T77873 |
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
|
|
98%
|
|
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC) activit...
|
T77889 |
NH2-methylpropanamide-Exatecan TFA
|
1817857-35-4
|
98%
|
|
Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.9...
|
T77901 |
Ac-Exatecan
|
2922852-48-8
|
98%
|
|
Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug conjugate (ADC) formulations (ADC Cytotoxin) and a...
|
T78630 |
Exatecan mesylate dihydrate
|
197720-53-9
|
98%
|
|
Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].
|
T78717 |
Topoisomerase inhibitor 2
|
2713986-17-3
|
98%
|
|
Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].
|
T78747 |
DiPT-4
|
|
98%
|
|
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to cir...
|
T79263 |
Antitumor agent-102
|
|
98%
|
|
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targets colorectal...
|
T79506 |
Topoisomerase II inhibitor 15
|
451516-79-3
|
98%
|
|
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].
|
T79539 |
Topoisomerase II inhibitor 16
|
2403729-27-9
|
98%
|
|
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the abi...
|
T79883 |
9-Chloromethyl-10-hydroxy-11-F-Camptothecin
|
2414594-22-0
|
98%
|
|
9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential application...
|
T80967 |
Topoisomerase I inhibitor 9
|
1228150-86-4
|
98%
|
|
Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value o...
|
T80968 |
Topoisomerase I inhibitor 10
|
|
98%
|
|
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity. Specifically, it demonstrat...
|
T82934 |
AuM1Phe
|
|
98%
|
|
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization. It also impedes the proliferation ...
|