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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T82935 AuM1Gly 98%
AuM1Gly
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the low ...
TQ0049 MC-DOXHZN hydrochloride 480998-12-7 98%
MC-DOXHZN hydrochloride
MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
TN4172 Guajadial B 1414455-03-0 98%
Guajadial B
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
T15200 Edotecarin 174402-32-5 98%
Edotecarin
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
TN2464 Eleutherin 478-36-4 98%
Eleutherin
Eleutherin is a natural product from Eleutherine americana
TN4173 Guajadial C 1529775-02-7 98%
Guajadial C
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
TN1889 Lupalbigenin 76754-24-0 98%
Lupalbigenin
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN5190 Tryprostatin A 171864-80-5 98%
Tryprostatin A
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
T72153 Topoisomerase IV inhibitor 1 2883403-42-5 98%
Topoisomerase IV inhibitor 1
Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for...
T72154 Topoisomerase IV inhibitor 2 2883403-36-7 98%
Topoisomerase IV inhibitor 2
Topoisomerase IV inhibitor 2 (compound 5d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.35 μM for TOPO IV and 0.55 μM for...
T73421 CPT-Se3 2968315-02-6 98%
CPT-Se3
CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. Thi...
T73422 CPT-Se4 2968315-03-7 98%
CPT-Se4
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance ...
T74364 SDOX 2921601-78-5 98%
SDOX
SDOX, a Doxorubicin (DOX) prodrug, selectively releases the active agent, DOX, in tumor cells with elevated glutathione (GSH) levels, thereby reducing inadverten...
TN1734 Heveaflavone 23132-13-0 98%
Heveaflavone
Heveaflavone inhibits Topoisomerase I and scavenges DPPH free radical with anti-proliferation and antioxidant effects.
T14703 Karenitecin 203923-89-1 98%
Karenitecin
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
T14953 Chloroquinoxaline sulfonamide 97919-22-7 98%
Chloroquinoxaline sulfonamide
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T15054 Daun02 290304-24-4 98%
Daun02
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
T1456 Doxorubicin 23214-92-8 98%
Doxorubicin
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 125537-92-0 98%
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
TN2953 3-Hydroxysarpagine 857297-90-6 98%
3-Hydroxysarpagine
3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used...
AuM1Gly
T82935
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the low ...
MC-DOXHZN hydrochloride
TQ0049
MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
Guajadial B
TN4172
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
Edotecarin
T15200
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Eleutherin
TN2464
Eleutherin is a natural product from Eleutherine americana
Guajadial C
TN4173
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
Lupalbigenin
TN1889
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
Tryprostatin A
TN5190
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
Topoisomerase IV inhibitor 1
T72153
Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for...
Topoisomerase IV inhibitor 2
T72154
Topoisomerase IV inhibitor 2 (compound 5d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.35 μM for TOPO IV and 0.55 μM for...
CPT-Se3
T73421
CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. Thi...
CPT-Se4
T73422
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance ...
SDOX
T74364
SDOX, a Doxorubicin (DOX) prodrug, selectively releases the active agent, DOX, in tumor cells with elevated glutathione (GSH) levels, thereby reducing inadverten...
Heveaflavone
TN1734
Heveaflavone inhibits Topoisomerase I and scavenges DPPH free radical with anti-proliferation and antioxidant effects.
Karenitecin
T14703
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Chloroquinoxaline sulfonamide
T14953
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
Daun02
T15054
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
Doxorubicin
T1456
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
3-Hydroxysarpagine
TN2953
3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used...
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