T82935 |
AuM1Gly
|
|
98%
|
|
AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the low ...
|
TQ0049 |
MC-DOXHZN hydrochloride
|
480998-12-7
|
98%
|
|
MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin. Doxorubicin is a DNA topoisomerase II inhibitor.
|
TN4172 |
Guajadial B
|
1414455-03-0
|
98%
|
|
Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines,...
|
T15200 |
Edotecarin
|
174402-32-5
|
98%
|
|
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
|
TN2464 |
Eleutherin
|
478-36-4
|
98%
|
|
Eleutherin is a natural product from Eleutherine americana
|
TN4173 |
Guajadial C
|
1529775-02-7
|
98%
|
|
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
|
TN1889 |
Lupalbigenin
|
76754-24-0
|
98%
|
|
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
|
TN5190 |
Tryprostatin A
|
171864-80-5
|
98%
|
|
Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mamm...
|
T72153 |
Topoisomerase IV inhibitor 1
|
2883403-42-5
|
98%
|
|
Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for...
|
T72154 |
Topoisomerase IV inhibitor 2
|
2883403-36-7
|
98%
|
|
Topoisomerase IV inhibitor 2 (compound 5d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.35 μM for TOPO IV and 0.55 μM for...
|
T73421 |
CPT-Se3
|
2968315-02-6
|
98%
|
|
CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. Thi...
|
T73422 |
CPT-Se4
|
2968315-03-7
|
98%
|
|
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance ...
|
T74364 |
SDOX
|
2921601-78-5
|
98%
|
|
SDOX, a Doxorubicin (DOX) prodrug, selectively releases the active agent, DOX, in tumor cells with elevated glutathione (GSH) levels, thereby reducing inadverten...
|
TN1734 |
Heveaflavone
|
23132-13-0
|
98%
|
|
Heveaflavone inhibits Topoisomerase I and scavenges DPPH free radical with anti-proliferation and antioxidant effects.
|
T14703 |
Karenitecin
|
203923-89-1
|
98%
|
|
Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
|
T14953 |
Chloroquinoxaline sulfonamide
|
97919-22-7
|
98%
|
|
Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
|
T15054 |
Daun02
|
290304-24-4
|
98%
|
|
Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
|
T1456 |
Doxorubicin
|
23214-92-8
|
98%
|
|
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
|
TN5133 |
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
|
125537-92-0
|
98%
|
|
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
|
TN2953 |
3-Hydroxysarpagine
|
857297-90-6
|
98%
|
|
3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used...
|