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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 125537-92-0 98%
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
TN2953 3-Hydroxysarpagine 857297-90-6 98%
3-Hydroxysarpagine
3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used...
T67909 TAK1 inhibitor 1326712-16-6 98%
TAK1 inhibitor
TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively. TAK1 inhibitor show...
TN4283 Isodiospyrin 20175-84-2 98%
Isodiospyrin
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
TN1886 Lucidin primeveroside 29706-59-0 98%
Lucidin primeveroside
Lucidin primeveroside (Lucidin 3-O-primeveroside) is a natural product isolated from the root powder of akane (Rubia akane) and can be used as a coloring agent a...
TN4422 Lauterine 28200-65-9 98%
Lauterine
Lauterine is a DNA topoisomerase inhibitor.
T15586 Intoplicine 125974-72-3 98%
Intoplicine
Intoplicine is an inhibitor of DNA topoisomerase I and II.
TN1169 1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside 1415729-43-9 98%
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
T14945 CH-0793076 534605-78-2 98%
CH-0793076
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
TQ0134 Podocarpusflavone A 22136-74-9 98%
Podocarpusflavone A
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
TN4107 Ganoderic acid X 86377-53-9 98%
Ganoderic acid X
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN4923 Rubicordifolin 849699-55-4 98%
Rubicordifolin
Rubicordifolin exhibits potent cytotoxic and antitumor activities.
T1703 SN-38 86639-52-3 99.97%
SN-38
SN-38 (NK012) is an active metabolite of CPT-11.
T3332 Isosteviol 27975-19-5 99.97%
Isosteviol
Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside ...
T28994L Topixantrone 2HCl 2514569-86-7 99.96%
Topixantrone 2HCl
Topixantrone 2HCl is a DNA topoisomerase inhibitor with antitumor activity for the study of gastric and prostate cancer.
T1095 Sparfloxacin 110871-86-8 99.95%
Sparfloxacin
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T3186 NU2058 161058-83-9 99.95%
NU2058
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
T0909L Nalidixic acid sodium salt 3374-05-8 99.94%
Nalidixic acid sodium salt
Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.
T9088 Topovale 500214-53-9 99.94%
Topovale
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibite...
T0132 Etoposide 33419-42-0 99.93%
Etoposide
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide ha...
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
3-Hydroxysarpagine
TN2953
3-Hydroxysarpagine is a natural product of Rauvolfia, Apocynaceae. The catalog number is TN2953 and the CAS number is 857297-90-6. 3-Hydroxysarpagine can be used...
TAK1 inhibitor
T67909
TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively. TAK1 inhibitor show...
Isodiospyrin
TN4283
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the min...
Lucidin primeveroside
TN1886
Lucidin primeveroside (Lucidin 3-O-primeveroside) is a natural product isolated from the root powder of akane (Rubia akane) and can be used as a coloring agent a...
Lauterine
TN4422
Lauterine is a DNA topoisomerase inhibitor.
Intoplicine
T15586
Intoplicine is an inhibitor of DNA topoisomerase I and II.
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-β-D-glucopyranoside
TN1169
1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside may have DNA topoisomerases I and II inhibitory activity and cytotoxicity.
CH-0793076
T14945
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast ca...
Podocarpusflavone A
TQ0134
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
Rubicordifolin
TN4923
Rubicordifolin exhibits potent cytotoxic and antitumor activities.
SN-38
T1703
SN-38 (NK012) is an active metabolite of CPT-11.
Isosteviol
T3332
Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside ...
Topixantrone 2HCl
T28994L
Topixantrone 2HCl is a DNA topoisomerase inhibitor with antitumor activity for the study of gastric and prostate cancer.
Sparfloxacin
T1095
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
NU2058
T3186
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
Nalidixic acid sodium salt
T0909L
Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.
Topovale
T9088
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibite...
Etoposide
T0132
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide ha...
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