Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.

Cat. No.	Product name	CAS No.	Purity
T0274	Cinoxacin	28657-80-9	99.93%
T0274	Cinoxacin (Compound 64716), an older synthetic antimicrobial, was related to the quinolone class of antibiotics. Its activity was similar to oxolinic acid and na...
T6010	Idarubicin hydrochloride	57852-57-0	99.93%
T6010	Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).
T0486L	Irinotecan Hydrochloride	100286-90-6	99.92%
T0486L	Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a...
T6228	Irinotecan	97682-44-5	99.92%
T6228	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand re...
T40159	(4-NH2)-Exatecan	2495742-21-5	99.89%
T40159	(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).
T1166	Ellipticine	519-23-3	99.88%
T1166	Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.0...
T0717	Enoxacin hydrate	84294-96-2	99.86%
T0717	Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T1625	Lomefloxacin hydrochloride	98079-52-8	99.86%
T1625	Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. ...
T6407	β-Lapachone	4707-32-8	99.86%
T6407	β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T11249L	Dxd	1599440-33-1	99.85%
T11249L	Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
T22456	Voreloxin hydrochloride	175519-16-1	99.85%
T22456	Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
T0902	Ofloxacin	82419-36-1	99.83%
T0902	Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, ...
T0717L	Enoxacin	74011-58-8	99.82%
T0717L	Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T16697	Pyronaridine tetraphosphate	76748-86-2	99.82%
T16697	Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour a...
TN4660	Niranthin	50656-77-4	99.8%
TN4660	Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitiv...
T0461	Berberine chloride	633-65-8	99.8%
T0461	Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to ...
T12337L	Oxaquin TEA		99.79%
T12337L	Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and cros...
T0125	Epirubicin hydrochloride	56390-09-1	99.79%
T0125	Epirubicin hydrochloride (Pharmorubicin) is an antineoplastic agent which can inhibit Topoisomerase.
T0465	Ellagic acid	476-66-4	99.76%
T0465	Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the ...
T3117	Marbofloxacin	115550-35-1	99.76%
T3117	Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.