Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.

Cat. No.	Product name	CAS No.	Purity
T67509	Cholesteryl Hemisuccinate	1510-21-0	99.61%
T67509	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, antic...
T1521	(±)-10-Hydroxycamptothecin	64439-81-2	99.58%
T1521	(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selective...
T5394	Prulifloxacin	123447-62-1	99.56%
T5394	Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomera...
T1511	Daunorubicin hydrochloride	23541-50-6	99.53%
T1511	Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein s...
TQ0063	Zoliflodacin	1620458-09-4	99.51%
TQ0063	Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against ...
T0250	Ciprofloxacin monohydrochloride	93107-08-5	99.5%
T0250	Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T2764	(S)-10-Hydroxycamptothecin	19685-09-7	99.48%
T2764	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T68896	Daniquidone	67199-66-0	99.47%
T68896	Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity that induces DN...
TQ0088	Exatecan Mesylate	169869-90-3	99.44%
TQ0088	Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
T26046	Razoxane	21416-67-1	99.42%
T26046	Razoxane is used as an antimitotic agent with immunosuppressive properties.
T1060	Flumequine	42835-25-6	99.4%
T1060	Flumequine (R-802) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a ...
T31011	Coralyne chloride	38989-38-7	99.35%
T31011	Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifie...
T1294	Fleroxacin	79660-72-3	99.34%
T1294	Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T3481	Bimolane	74550-97-3	99.29%
T3481	Bimolane is a topoisomerase II inhibitor.
T0909	Nalidixic acid	389-08-2	99.22%
T0909	Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of ba...
TN1375	α-Lapachone	4707-33-9	99.17%
TN1375	α-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
T8498	EIDD-1931	3258-02-4	99.14%
T8498	EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus...
T1020	Doxorubicin hydrochloride	25316-40-9	99.13%
T1020	Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
T13231L	Trovafloxacin mesylate	147059-75-4	99.12%
T13231L	Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. ...
T1121	Podofilox	518-28-5	99.07%
T1121	Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken int...