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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T31011 Coralyne chloride 38989-38-7 99.35%
Coralyne chloride
Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifie...
T1294 Fleroxacin 79660-72-3 99.34%
Fleroxacin
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T3481 Bimolane 74550-97-3 99.29%
Bimolane
Bimolane is a topoisomerase II inhibitor.
T0974 Novobiocin Sodium 1476-53-5 99.28%
Novobiocin Sodium
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
T0909 Nalidixic acid 389-08-2 99.22%
Nalidixic acid
Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of ba...
TN1375 α-Lapachone 4707-33-9 99.17%
α-Lapachone
α-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
T8498 EIDD-1931 3258-02-4 99.14%
EIDD-1931
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus...
T1020 Doxorubicin hydrochloride 25316-40-9 99.13%
Doxorubicin hydrochloride
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
T13231L Trovafloxacin mesylate 147059-75-4 99.12%
Trovafloxacin mesylate
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. ...
T1121 Podofilox 518-28-5 99.07%
Podofilox
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken int...
TN1037 Groenlandicine 38691-95-1 99.03%
Groenlandicine
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recom...
T0425L Pefloxacin Mesylate Dihydrate 149676-40-4 99.03%
Pefloxacin Mesylate Dihydrate
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
T28475 Pyrazoloacridine 99009-20-8 98.99%
Pyrazoloacridine
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine ...
T16286 Nelonemdaz 640290-67-1 98.95%
Nelonemdaz
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
T5S0761 Nitidine chloride 13063-04-2 98.91%
Nitidine chloride
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T26339L XR-11576 HCl T26339L 98.89%
XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.
T4614 Ellipticine hydrochloride 5081-48-1 98.85%
Ellipticine hydrochloride
Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
T1174 Topotecan hydrochloride 119413-54-6 98.76%
Topotecan hydrochloride
Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.
T6628 Pirarubicin 72496-41-4 98.66%
Pirarubicin
Pirarubicin (Theprubicin) is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II...
T0158 Mitoxantrone dihydrochloride 70476-82-3 98.63%
Mitoxantrone dihydrochloride
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase ...
Coralyne chloride
T31011
Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifie...
Fleroxacin
T1294
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
Bimolane
T3481
Bimolane is a topoisomerase II inhibitor.
Novobiocin Sodium
T0974
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
Nalidixic acid
T0909
Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of ba...
α-Lapachone
TN1375
α-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
EIDD-1931
T8498
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus...
Doxorubicin hydrochloride
T1020
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). ...
Trovafloxacin mesylate
T13231L
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. ...
Podofilox
T1121
Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken int...
Groenlandicine
TN1037
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recom...
Pefloxacin Mesylate Dihydrate
T0425L
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
Pyrazoloacridine
T28475
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine ...
Nelonemdaz
T16286
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
Nitidine chloride
T5S0761
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
XR-11576 HCl
T26339L
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.
Ellipticine hydrochloride
T4614
Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
Topotecan hydrochloride
T1174
Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.
Pirarubicin
T6628
Pirarubicin (Theprubicin) is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II...
Mitoxantrone dihydrochloride
T0158
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase ...
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TargetMol