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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1492 Gemifloxacin mesylate 210353-53-0 98%
Gemifloxacin mesylate
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial...
T7551 Belotecan hydrochloride 213819-48-8 98%
Belotecan hydrochloride
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
T16697 Pyronaridine tetraphosphate 76748-86-2 98%
Pyronaridine tetraphosphate
Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour a...
T24610 Pegamotecan 581079-18-7 97.96%
Pegamotecan
Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung...
T6567 Levofloxacin 100986-85-4 97.63%
Levofloxacin
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastroin...
T6628 Pirarubicin 72496-41-4 97.61%
Pirarubicin
Pirarubicin (Theprubicin) is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II...
TN1917 Mauritianin 109008-28-8 97.5%
Mauritianin
Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica and is a topoisomerase I inhibitor.Mauritianin has cytoprotective a...
T7187 Genz-644282 529488-28-6 97.49%
Genz-644282
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
T2160 Suramin Sodium Salt 129-46-4 97.47%
Suramin Sodium Salt
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
T60163 Lurtotecan 149882-10-0 97.08%
Lurtotecan
Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.
T21319L Gimatecan HCl T21319L 97.04%
Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
T15578 Indotecan 915303-09-2 97%
Indotecan
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
T5S0761 Nitidine chloride 13063-04-2 96.59%
Nitidine chloride
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T3339 Sophoridine 6882-68-4 96.35%
Sophoridine
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivat...
T4S0797 Berberine 2086-83-1 95.71%
Berberine
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial m...
T5784 Topotecan 123948-87-8 95.19%
Topotecan
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
T8333 Aurintricarboxylic acid 4431-00-9 95%
Aurintricarboxylic acid
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by ...
T0425 Pefloxacin Mesylate 70458-95-6 100%
Pefloxacin Mesylate
Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positiv...
T6228 Irinotecan 97682-44-5 100%
Irinotecan
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand re...
T11090L1 Aldoxorubicin hydrochloride 1361563-03-2 100%
Aldoxorubicin hydrochloride
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
Gemifloxacin mesylate
T1492
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial...
Belotecan hydrochloride
T7551
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
Pyronaridine tetraphosphate
T16697
Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour a...
Pegamotecan
T24610
Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell lung...
Levofloxacin
T6567
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastroin...
Pirarubicin
T6628
Pirarubicin (Theprubicin) is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II...
Mauritianin
TN1917
Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica and is a topoisomerase I inhibitor.Mauritianin has cytoprotective a...
Genz-644282
T7187
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
Suramin Sodium Salt
T2160
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
Lurtotecan
T60163
Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.
Gimatecan HCl
T21319L
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
Indotecan
T15578
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
Nitidine chloride
T5S0761
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
Sophoridine
T3339
Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivat...
Berberine
T4S0797
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial m...
Topotecan
T5784
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
Aurintricarboxylic acid
T8333
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by ...
Pefloxacin Mesylate
T0425
Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positiv...
Irinotecan
T6228
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand re...
Aldoxorubicin hydrochloride
T11090L1
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor. Aldoxorubicin hydrochloride is released from albumin ...
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