T78968 |
TRK-IN-23
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2924344-29-4
|
98%
|
|
TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, a...
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T79011 |
TrkB-IN-1
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1609067-49-3
|
98%
|
|
TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties. It has been shown to reverse cognitive deficit...
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T79125 |
Protein kinase inhibitor 5
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2278204-94-5
|
98%
|
|
Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].
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T79126 |
Protein kinase inhibitor 5 sulfate hydrate
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|
98%
|
|
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].
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T79706 |
TRK-IN-24
|
2937544-01-7
|
98%
|
|
TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, wi...
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T81740 |
Multi-kinase-IN-6
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|
98%
|
|
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhi...
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T13208 |
TrkA-IN-1
|
1680179-43-4
|
98%
|
|
TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.
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T6936 |
PF-03814735
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942487-16-3
|
98%
|
|
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
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T13207 |
PF-06733804
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1873373-33-1
|
98%
|
|
PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
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TN2890 |
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one
|
244277-75-6
|
98%
|
|
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one is a natural product of Euphorbia, Euphorbiaceae. The catalog number is TN2890 and the CAS num...
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T17000 |
Tavilermide
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263251-78-1
|
98%
|
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Tavilermide is a selective and partial agonist of TrkA or a nerve growth factor mimetic.
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T72289 |
Type II TRK inhibitor 1
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2937543-72-9
|
98%
|
|
Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstra...
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T73033 |
TRK II-IN-1
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2904690-41-9
|
98%
|
|
TRK II-IN-1 is a potent type II inhibitor of tropomyosin receptor kinases (TRK), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 3.3, ...
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T17170 |
PF-06737007
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1863905-38-7
|
98%
|
|
PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).
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T17169 |
Trk-IN-4
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1799788-94-5
|
98%
|
|
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
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T22318 |
Taletrectinib
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1505515-69-4
|
99.96%
|
|
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980...
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T2359 |
ANA-12
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219766-25-3
|
99.87%
|
|
ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
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T4071 |
Repotrectinib
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1802220-02-5
|
99.86%
|
|
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
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T6081 |
Milciclib
|
802539-81-7
|
99.73%
|
|
Milciclib (PHA-848125) (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4...
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T3678 |
Entrectinib
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1108743-60-7
|
99.61%
|
|
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1....
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