T3109 |
SP600125
|
129-56-6
|
99.58%
|
|
SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive proper...
|
T6880 |
Larotrectinib sulfate
|
1223405-08-0
|
99.49%
|
|
Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).
|
T4257 |
Belizatinib
|
1357920-84-3
|
99.48%
|
|
Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
|
T40034 |
GNF-8625 monopyridin-N-piperazine hydrochloride
|
2412055-62-8
|
99.44%
|
|
GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.
|
TP2068L |
Cyclotraxin B acetate(1203586-72-4 free base)
|
TP2068L
|
99.42%
|
|
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation ...
|
T6097 |
GNF-5837
|
1033769-28-6
|
99.29%
|
|
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
|
T22324 |
Ensartinib hydrochloride
|
2137030-98-7
|
99.29%
|
|
Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known cr...
|
T73397 |
ENT-C225
|
2919962-53-9
|
99.16%
|
|
ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.
|
T6712 |
Tyrphostin AG 879
|
148741-30-4
|
99.05%
|
|
Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
|
T14921 |
CE-245677
|
717899-97-3
|
98.99%
|
|
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
|
T4349 |
Sitravatinib
|
1123837-84-2
|
98.9%
|
|
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Ax...
|
T2349 |
BMS-754807
|
1001350-96-4
|
98.86%
|
|
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine ...
|
T2094 |
Danusertib
|
827318-97-8
|
98.44%
|
|
Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinase...
|
T2816 |
7,8-Dihydroxyflavone
|
38183-03-8
|
98.37%
|
|
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.
|
T6121 |
Tepotinib
|
1100598-32-0
|
98.35%
|
|
Tepotinib (EMD-1214063) is an inhibitor of MET tyrosine kinase with potential antineoplastic activity.
|
T8327 |
ONO-7475
|
1646839-59-9
|
98.33%
|
|
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
|
T41224 |
CG 428
|
2412055-93-5
|
98.26%
|
|
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 jo...
|
T4496 |
LM22B-10
|
342777-54-2
|
98.19%
|
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
|
T1354 |
N-Acetyl-5-hydroxytryptamine
|
1210-83-9
|
98.03%
|
|
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the en...
|
T5635 |
CH7057288
|
2095616-82-1
|
98%
|
|
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
|