Tyrosine Kinases

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase.The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subgroup of the larger class of protein kinases that attach phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.

Cat. No.	Product name	CAS No.	Purity
T2487	Cerdulatinib	1198300-79-6	99.64%
T2487	Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.
T4209	TAK-659 hydrochloride	1952251-28-3	99.63%
T4209	TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most ot...
TN1440	Beta-Hydroxyisovalerylshikonin	7415-78-3	99.59%
TN1440	Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor ...
T12266L2	Ilginatinib hydrochloride	1239358-85-0	99.55%
T12266L2	Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.
T6080	NVP-AEW541	475489-16-8	99.55%
T6080	NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based as...
T6020	Pacritinib	937272-79-2	99.52%
T6020	Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).
T6156	Ruxolitinib (S enantiomer)	941685-37-6	99.5%
T6156	Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.
T12266	Ilginatinib	1239358-86-1	99.43%
T12266	Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.
T22416	RO495	1258296-60-4	99.4%
T22416	RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays
T4210	SAR-20347	1450881-55-6	99.35%
T4210	SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
T63746	Vamotinib	1416241-23-0	99.34%
T63746	Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylati...
T6104	Cerdulatinib hydrochloride	1369761-01-2	99.23%
T6104	Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for ...
T3076	GLPG0634 analog	1206101-20-3	99.22%
T3076	GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
T6S0923	Hypericin	548-04-9	99.17%
T6S0923	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhib...
T6914	Oclacitinib maleate	1640292-55-2	99.17%
T6914	Oclacitinib maleate (PF-03394197 maleate) is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ra...
T4511	ST271	106392-48-7	98.94%
T4511	ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
T6294	NVP-BSK805 2HCl (1092499-93-8(free base))	T6294	98.75%
T6294	NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over ...
T3080	Pyridone 6	457081-03-7	98.7%
T3080	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); ...
T8697	ZAP-180013	873080-25-2	98.63%
T8697	ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).
T14687	Deucravacitinib	1609392-27-9	98.52%
T14687	Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for...