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Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T67777 Flaviviruses-IN-3 420090-97-7 99.39%
Flaviviruses-IN-3
Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruse. Flaviviruses-IN-3 could reduce the WNV (West Nile virus) protease activity, with a inhibiti...
T0825 Ebselen 60940-34-3 99.38%
Ebselen
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimet...
T72051 LabMol-319 381188-63-2 99.36%
LabMol-319
LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.
T1848 Dynasore 304448-55-3 99.22%
Dynasore
Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-fre...
T5013 Brequinar 96187-53-0 99.21%
Brequinar
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
TMO2787 Anthraquinone 84-65-1 99.2%
Anthraquinone
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.
T0495 Aminothiazole 96-50-4 99.18%
Aminothiazole
Aminothiazole (2-Aminothiazole), a thyroid inhibitor, displays antibacterial activity.
T16914 SP187 615253-61-7 99.18%
SP187
SP187 (MON-​DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.
T8498 EIDD-1931 3258-02-4 99.14%
EIDD-1931
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus...
T3759 3,4-Dimethoxycinnamic acid 2316-26-9 99.07%
3,4-Dimethoxycinnamic acid
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exert...
T0800 Danthron 117-10-2 99.03%
Danthron
Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T0122 Bergenin 477-90-7 99.01%
Bergenin
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T3345 Hederasaponin B 36284-77-2 98.99%
Hederasaponin B
Hederasaponin B (Hederacoside B) has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.
T2432 PD 169316 152121-53-4 98.83%
PD 169316
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
T12711 Retro-2 cycl 1429192-00-6 98.82%
Retro-2 cycl
Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 1...
T4S0999 (2S)-Isoxanthohumol 70872-29-6 98.82%
(2S)-Isoxanthohumol
1. (2S)-Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphen...
T20510 Novobiocin 303-81-1 98.72%
Novobiocin
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on...
T3324 Lycorine 476-28-8 98.71%
Lycorine
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T5429 Theaflavin 3,3'-digallate 30462-35-2 98.71%
Theaflavin 3,3'-digallate
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopre...
T1750 Pirodavir 124436-59-5 98.66%
Pirodavir
Pirodavir (R77975) (R 77975), the prototype of broad-spectrum anti-picornavirus compounds, is a potent human rhinovirus (HRV) capsid-binding inhibitor.
Flaviviruses-IN-3
T67777
Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruse. Flaviviruses-IN-3 could reduce the WNV (West Nile virus) protease activity, with a inhibiti...
Ebselen
T0825
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimet...
LabMol-319
T72051
LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.
Dynasore
T1848
Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-fre...
Brequinar
T5013
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
Anthraquinone
TMO2787
Anthraquinone (Anthradione)s are the main active constituents in herbs often used to relieve constipation.
Aminothiazole
T0495
Aminothiazole (2-Aminothiazole), a thyroid inhibitor, displays antibacterial activity.
SP187
T16914
SP187 (MON-​DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.
EIDD-1931
T8498
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus...
3,4-Dimethoxycinnamic acid
T3759
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exert...
Danthron
T0800
Danthron (Antrapurol) is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
Bergenin
T0122
Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Hederasaponin B
T3345
Hederasaponin B (Hederacoside B) has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.
PD 169316
T2432
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
Retro-2 cycl
T12711
Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 1...
(2S)-Isoxanthohumol
T4S0999
1. (2S)-Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphen...
Novobiocin
T20510
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on...
Lycorine
T3324
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
Theaflavin 3,3'-digallate
T5429
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopre...
Pirodavir
T1750
Pirodavir (R77975) (R 77975), the prototype of broad-spectrum anti-picornavirus compounds, is a potent human rhinovirus (HRV) capsid-binding inhibitor.
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TargetMol