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Description | Phytohemagglutinin P (PHA-P) is a mitogen that selectively stimulates hematogenous or lymphoid monocytic cells [1]. |
In vitro | Activation of decidual CD8+ T lymphocytes by phytohemagglutinin-P (10 μg/ml; 24-48 hours) increases interferon gamma and interleukin (IL) 8 production, while decreasing granulocyte-macrophage colony-stimulating factor (CSF2), IL1B, IL2, IL6, IL10, IL12, and tumor necrosis factor secretion, independent of gestational age [2]. |
In vivo | Phytohemagglutinin-P, administered intraperitoneally at doses of 25 and 50 mg/kg daily for 15 days to male Sprague-Dawley rats, resulted in a reduction of longitudinal bone growth, chondrocyte numbers, cartilage plate thickness, metaphyseal hard tissue mass, calcified cartilage core percentage, and osteoblast count per millimeter of bone surface. Furthermore, PHA-P elevated osteoclast quantity, osteoclastic nuclei labeling, and the average nuclei count per osteoclast [1]. |
Alias | PHA-P |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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