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Vixtimotamab
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Catalog No. T80858
Alias TandAb T564, AMV-564
Vixtimotamab (AMV-564; TandAb T564), a bispecific tetravalent tandem diabody (TandAb), selectively targets human CD33 and CD3 antigens, and is used in acute myeloid leukemia (AML) research [1].
Vixtimotamab
Vixtimotamab
😃Good
Catalog No. T80858Alias TandAb T564, AMV-564
Vixtimotamab (AMV-564; TandAb T564), a bispecific tetravalent tandem diabody (TandAb), selectively targets human CD33 and CD3 antigens, and is used in acute myeloid leukemia (AML) research [1].
| Pack Size | Price | Availability | Quantity |
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| 1 mg | Inquiry | Backorder | |
| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Vixtimotamab (AMV-564; TandAb T564), a bispecific tetravalent tandem diabody (TandAb), selectively targets human CD33 and CD3 antigens, and is used in acute myeloid leukemia (AML) research [1]. |
| In vitro | Vixtimotamab (TandAb T564; 24 h) induces CD25 and CD69 with EC50 values of 1 pM and 2 pM, respectively [1]. Additionally, Vixtimotamab (TandAb T564; 4 days) promotes T-cell proliferation in PBMCs with an EC50 of 3 pM [1]. Furthermore, Vixtimotamab (TandAb T564; 25 pM, 48 h) exhibits cytotoxicity against HL-60 and KG-1a cells [1]. |
| In vivo | Vixtimotamab (TandAb T564; 0.1-10 μg/mouse, i.v.; 5 days) demonstrated a dose-dependent delay in tumor growth in a prophylactic HL-60 xenografted NOD/scid mouse model [1]. Additionally, vixtimotamab (TandAb T564; 50 μg/mouse/d, i.v.; 7 days) significantly inhibited tumor growth in an established HL-60 xenografted NOD/scid mouse model [1]. |
| Alias | TandAb T564, AMV-564 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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