[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.

6-OH-BTA-0 is the precursor for preparing 11C-PiB, which is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.

OfHex1-IN-1 (compound 11c), a β-N-acetylhexosaminidase from Ostrinia furnacalis inhibitor, exhibits high potency and selectivity with an IC50 of 28.1 μM and a K i of 25.6 μM. It is applicable in research for developing green pesticides related to OfHex1 [1].

CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.

Desmethyl-HD-800 is a PET precursor of preparing radiolabel [11C]HD-800, a high affinity brain penetrant PET tracer for imaging microtubules.

LSN3172176 Precursor is a precursor for 11C-radiolabelling LSN3172176 PET scan.

(R)-N-Desmethyl PK11195 is a precursor for (R)-[N-Methyl-11C-]PK11195.

Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) is a unique component of the cell wall of Gram-negative bacteria, consisting of three regions: lipid A, oligosaccharide core and O-specific polysaccharide (O-antigen). Lipopolysaccharides, Escherichiacoli helps maintain the integrity of the outer cell membrane and protects bacteria from damage by bile salts and lipid antibiotics. Lipopolysaccharides, Escherichiacoli is a highly immunogenic antigen that can enhance immune responses and can be used for inflammation model construction.

SSI-4 is a Stearoyl CoA desaturase 1 (SCD1) inhibitor that can be labeled with carbon-11 (11C) for use as a ligand in small animal in vivo PET/CT imaging studies of SCD1 [1].

Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM. It demonstrates cell proliferation inhibition in SJSA-1, MDA-MB-231, A549, and HeLa cell lines with IC50 values of 4.27, 1.54, 3.08, and 6.99 μM, respectively. This compound is applicable in research concerning triple-negative breast cancer (TNBC) [1].

PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].

Lipopolysaccharides (LPS) is a unique component of the cell wall of Gram-negative bacteria and consists of three regions: lipid A, oligosaccharide core, and O-specific polysaccharide (O-antigen). Lipopolysaccharides help maintain the integrity of the outer cell membrane and protect bacteria from damage by bile salts and lipid antibiotics. Lipopolysaccharides is a highly immunogenic antigen that can enhance immune responses and can be used for inflammation model construction.