15,18dihydroxyabieta8,11,13trien7one

AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively).

3β-Acetoxyurs-12-en-11-one (11-Ketoamyrinacetate) is an ursane triterpene natural product found in the stem bark of Morus mesozygia and the leaves of Ficus hirta Vahl (Moraceae).

Orphanin FQ(1-11) acetate(178249-41-7 free base) is a peptide fragment containing amino acids 1-11 of Nociceptin. Orphanin FQ(1-11) acetate(178249-41-7 free base) is a potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM) and displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Orphanin FQ(1-11) acetate(178249-41-7 free base) displays analgesic properties in CD-1 mice.

3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one is a compound that has been extensively investigated for the treatment of a variety of disorders including tumors, Alzheimer's and Parkinson's diseases, anti-inflammatory drugs, and analgesic agents.

Ganoderic acid 24, chemically designated as lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid, exhibits significant cytotoxicity against various cancer cell lines, including human lung cancer cells CH27, melanoma cells M21, and oral cancer cells HSC-3 [1].

7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB) is a natural product for research related to life sciences. The catalog number is TN3217 and the CAS number is 79559-60-7.

Fern-7-en-19-one is a natural product for research related to life sciences. The catalog number is TN4055 and the CAS number is 222294-61-3.

enantio-7(11)-Eudesmen-4-ol is a natural product for research related to life sciences. The catalog number is TN3929 and the CAS number is 186374-63-0.

3β-(Acetyloxy)stigmast-5-en-7-one exhibits anti-complement activity [1].

7-Epi-5-eudesmene-1beta,11-diol is a natural product for research related to life sciences. The catalog number is TN3224 and the CAS number is 87261-77-6.

15,16-Dinor-8(17),11-labdadien-13-one is a natural product for research related to life sciences. The catalog number is TN2630 and the CAS number is 76497-69-3.

Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

7-Hydroxy-3-(4'-hydroxybenzylidene)-chroman-4-one may have anti-inflammatory activity.

Selina-4(15),7(11)-dien-8-one is a natural product for research related to life sciences. The catalog number is TN3467 and the CAS number is 54707-47-0.

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

7-Aminomethyl-10-methyl-11-fluoro camptothecin, serving as a cytotoxic component of the antibody-drug conjugate (ADC) MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin, is employed in the synthesis of camptothecin ADCs [1].

Stigmasta-3,5-dien-7-one is a steroid derivative sourced from Harrisonia abyssinica [1].

18-Nor-4,15-dihydroxyabieta-8,11,13-trien-7-one shows moderate cytotoxicity against a human lung carcinoma cell line.

4(15),11-Oppositadien-1-ol is a natural product for research related to life sciences. The catalog number is TN2996 and the CAS number is 70389-96-7.

The compound 6-[(1R,2S)-2,3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxy has been isolated from the stem of Angelica dahurica, marking its first discovery from a plant source [1].

11-Hydroxy-canthin-6-one has antineoplastic activity.

4,8-Dihydroxyeudesm-7(11)-en-12,8-olide is a natural product for research related to life sciences. The catalog number is TN3017 and the CAS number is 1231208-53-9.

1,7-Bis(4-hydroxyphenyl)hepta-1,4,6-trien-3-one is a natural product for research related to life sciences. The catalog number is TN6235 and the CAS number is 149732-52-5.

Eudesm-4(15)-ene-3alpha,11-diol is a compound derived from Eudesm-4(15)-ene-3alpha,11-diol.

Lanosta-7,9(11),24-trien-3β,15α-dihydroxy-26-oic acid (compound 2) is a natural product isolated from the Chinese medicinal fungus Ganoderma lucidum [1].

3-Acetoxy-4,7(11)-cadinadien-8-one is a natural product for research related to life sciences. The catalog number is TN2916 and the CAS number is 104975-02-2.

5-Hydroxy-7-methoxy-3-(4-hydroxybenzylidene)chroman-4-one is a natural product for research related to life sciences. The catalog number is TN3121 and the CAS number is 259653-54-8.

5-Hydroxy-3-(4-hydroxybenzyl)-7-methoxychroman-4-one is a natural product of Agave, Amaryllidaceae. The catalog number is TN3072 and the CAS number is 108001-32-7. 5-Hydroxy-3-(4-hydroxybenzyl)-7-methoxychroman-4-one can be used as a reference standard.

6,9,10-Trihydroxy-7-megastigmen-3-one is a natural product for research related to life sciences. The catalog number is TN5338 and the CAS number is 476682-97-0.

7-Hydroxy-4H-chromen-4-one (7-hydroxy-4-benzopyrone) is a Src kinase inhibitor (IC50 of <300 μM).

15,18-Dihydroxyabieta-8,11,13-trien-7-one is a natural product of Pinus, Pinaceae. The catalog number is TN2634 and the CAS number is 213329-45-4. 15,18-Dihydroxyabieta-8,11,13-trien-7-one can be used as a reference standard.

Eledoisin (7-11) is a peptide.

(3β,24S)-3-Hydroxystigmast-5-en-7-one (Compound 31), isolated from Lindera akoensis, exhibits anti-inflammatory activity [1].

7-Amino-2H-chromen-2-one is a useful organic compound for research related to life sciences and the catalog number is T64948.

3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one is a natural product of Euphorbia, Euphorbiaceae. The catalog number is TN2890 and the CAS number is 244277-75-6. 3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one can be used as a reference standard.

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

1,10:4,5-Diepoxy-7(11)-germacren-8-one is a natural product for research related to life sciences. The catalog number is TN2476 and the CAS number is 32179-18-3.

3β-Hydroxyporiferast-5-en-7-one is a useful organic compound for research related to life sciences and the catalog number is T125845.

7-(4-Hydroxyphenyl)-5-methoxy-1-phenylheptan-3-one is a natural product for research related to life sciences. The catalog number is TN6372 and the CAS number is 100667-53-6.

Stigmasta-4,22,25-trien-3-one is a natural product from Callicarpa giraldiana.

[Ala1,3,11,15]-Endothelin (TFA) is a highly selective for endothelin A (ETA) and endothelin B (ETB) receptor.[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ET

Dibenzo[b,e]oxepin-11(6H)-one is a useful organic compound for research related to life sciences. The catalog number is T65977 and the CAS number is 4504-87-4.

3,14,20-trihydroxypregn-5-en-15-one is a useful organic compound for research related to life sciences and the catalog number is T131419.

6β-Ethoxy-8β,10β-dihydroxyeremophil-7(11)-en-12,8α-olide is a useful organic compound for research related to life sciences and the catalog number is T125285.

13-Acetoxy-3beta-hydroxygermacra-1(10)E,4E,7(11)-trien-12,6alpha-olide is a natural product from Artemisia myriantha.

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD).

11-Hydroxydrim-7-en-6-one is a natural product for research related to life sciences. The catalog number is TN2584 and the CAS number is 74635-87-3.

11-Hydroxybisabola-1,3,5-trien-9-one is a natural product for research related to life sciences. The catalog number is TN2582 and the CAS number is 61235-23-2.

Nucleoside Derivatives - 7-Deaza-purine nucleoside

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is a useful organic compound for research related to life sciences. The catalog number is T65438 and the CAS number is 31251-41-9.