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Results for "

MLK

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    17
    TargetMol | Activity
  • PROTAC Products
    1
    TargetMol | inventory
  • Recombinant Protein
    1
    TargetMol | natural
MLKL-IN-2
T41027899759-16-1In house
MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.
  • $106
In Stock
Size
QTY
(E/Z)-Necrosulfonamide
T7129432531-71-0
(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
LY-364947
T2048396129-53-6
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
  • $59
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Necrosulfonamide
T69041360614-48-7
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.
  • $52
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
PRT062607 hydrochloride
T26961370261-97-4
PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
  • $55
In Stock
Size
QTY
TargetMol | Inhibitor Sale
IM-54
T24160861891-50-1
IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
URMC-099
T60571229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
  • $52
In Stock
Size
QTY
AZ7550 trimesylate salt
T13564L22319837-99-3
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.
  • $149
In Stock
Size
QTY
GW806742X
T11520579515-63-2
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
AZ7550
T135641421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
  • $133
In Stock
Size
QTY
Cerdulatinib hydrochloride
T61041369761-01-2
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
  • $37
In Stock
Size
QTY
MLK-IN-2
T869102614255-51-3
MLK-IN-2 (Compound 9a), with its 3H-imidazole [4,5-b] pyridine structure, serves as a potent Mixed Lineage Kinase 3 (MLK3) inhibitor with an IC50 value of 6 nM. This compound is valuable for research in cancer and neurodegenerative diseases [1].
  • Inquiry Price
10-14 weeks
Size
QTY
MLK-IN-1
T391021627729-62-7
MLK-IN-1 (US20140256733A1, compound 68) is a highly potent and selective inhibitor of mixed lineage kinase 3 (MLK-3). It exhibits excellent brain penetration and specifically targets MLK-3.
    7-10 days
    Inquiry
    MLKL-IN-6
    T79731
    MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are critical steps in cell necrosis. Additionally, MLKL-IN-6 restrains immune cell death, diminishes adhesion factor expression, exhibits low cytotoxicity, impedes hepatic stellate cell activation, decreases liver fibrosis marker levels, and exerts anti-fibrotic effects [1].
    • Inquiry Price
    Size
    QTY
    MLKL-IN-5
    T732792755872-58-1
    MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis.
    • $1,520
    6-8 weeks
    Size
    QTY
    PROTAC MLKL Degrader-1
    T79831
    PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, with a degradation maximum (D max) exceeding 90%. The compound incorporates modified cereblon (CRBN) ligands and a lenalidomide-linker within its structure, effectively inhibiting cell death in a TSZ-induced model of necroptosis.
    • Inquiry Price
    Size
    QTY
    MLKL-IN-1
    T60885
    MLKL-IN-1, a covalent inhibitor of MLKL, has a dissociation constant (Kd) of 50 μM.
    • $1,520
    10-14 weeks
    Size
    QTY