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act132577

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Aprocitentan
T78171103522-45-7
Aprocitentan (ACT-132577) is ETA and ETB antagonist .
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Aprocitentan D4
T10351
Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5).
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