adrenocorticotropic hormone (acth) (4 10) tfa

Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) is an agonist of potent melanocortin(MC4R) receptor .

Potent, selective agonist of Mu-opioid receptor. Antinociceptive. Stimulates calcium-activated adenylyl cyclases related cAMP production. Expresses chemokines and chemokine receptors through TGF-beta1. Increases food intake of rats.

Adrenocorticotropic Hormone (ACTH) (1-10), human acetate is a fragment of adrenocorticotropin hormone. Adrenocorticotropic Hormone (ACTH) (1-10), human acetate possesses a weak α-MSH potency only at 100 and 1000 nM.

Dynorphin A (1-10) acetate is an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.

Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression

Highy selective and potent NK2 receptor agonist (IC50 = 6.1 nM). Induces contraction of the rat fundus and bladder (EC50 values are 117 and 10 nM respectively).

Acth (1-4) acetate is the ACTH N-terminal tetrapeptide.

ACTH 4-11 acetate is an adrenocorticotropin hormone fragment and possesses the same amino acid sequence as α-melanocyte stimulating hormone (MSH) does. ACTH 4-11 acetate exhibits a weak MSH potency only at high doses (100 and 1000 nM).

Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].

tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.

Saralasin acetate is a Non-selective angiotensin II antagonist.

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4) that does not affect PAR-1 or PAR-2, and its activity can be inhibited by a PAR-4 antagonist.

Adrenocorticotropic Hormone (ACTH) (18-39), human TFA (CLIP human TFA) is a corticotropin-like intermediate lobe peptide produced in the melanotrophs of the pituitary's intermediate lobe.

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist [1].

ACTH (1-14) (TFA) is a regulatory fragment of adrenocorticotropin, involved in controlling cortisol and androgen synthesis [1].

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, is a selective and potent NK2 receptor (NK2R) agonist with prokinetic activity, making it valuable for researching smooth muscle contractions across various tissues through NK-2 receptor engagement [1][2][3].

(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent neurokinin-3 (NK3) antagonist [1].

(p-Iodo-Phe7)-ACTH (4-10), a derivative of adrenocorticotrophic hormone (ACTH) produced by the anterior pituitary gland, functions as a melanocortin (MC) receptor antagonist and effectively inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats [1].

Adrenocorticotropic hormone (ACTH), a polypeptide tropic hormone secreted by the anterior pituitary gland, regulates cortisol and androgen production [1] [2].

Adrenocorticotropic Hormone (ACTH) (4-10) is a potent agonist of the melanocortin receptor (MC4R).

1,3-dihydroxy-4-methoxy-10-methylacridin-9-one is a natural product for research related to life sciences. The catalog number is TN2491 and the CAS number is 1189362-86-4.

Magainin 1 TFA is an antimicrobial amphiphilic peptide isolated from xenopus skin.

SLLK, Control Peptide for TSP1 Inhibitor (TFA) is a control peptide for LSKL, which is a Thrombospondin (TSP-1) inhibitor.

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

Adrenocorticotropic Hormone (ACTH) (1-39), rat, is a potent melanocortin 2 (MC2) receptor agonist. Peptide fragments of ACTH (1-39) were formed during in vitro incubation with membrane preparations, isolated by high-pressure liquid chromatography, and characterized by determining their amino acid composition and NH2-terminal residue.

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2, a melanotropin derivative and melanocyte-stimulating hormone, activates tyrosinase and demonstrates a thermoregulatory effect in rat models [1][2].

POT-4 TFA (AL-78898A TFA), a derivative of Compstatin, efficiently inhibits the activation of complement factor C3 and is utilized in research related to age-related macular degeneration [1] [2].

TLR7 8 agonist 4 TFA (compound 41) is a highly potent TLR7 8 agonist demonstrating significant anti-cancer activity.

ERK1/2 inhibitor

20)abeotaxa-4(20),11-dien-10-one'>2alpha,7beta,13alpha-Triacetoxy-5alpha-cinnamoyloxy-9beta-hydroxy-2(3->20)abeotaxa-4(20),11-dien-10-one is a natural product for research related to life sciences. The catalog number is TN2840 and the CAS number is 322471-42-1.

PROTAC AR Degrader-4, an Androgen Receptor (AR) degrader, incorporates an IAP ligand binding group, a linker, and an AR binding group. It represents a class of degradation inducers known as specific and non-genetic IAP-dependent protein erasers (SNIPERs) [1], operating through a mechanism involving cIAP1.

Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system.

ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM.

Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in th

Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure.

Chemerin-9 (149-157) TFA, the nonapeptide (149)YFPGQFAFS(157) (chemerin-9), corresponding to the C terminus of processed chemerin, retains most of the activity of the full-size protein, with regard to agonism toward the chemerinR[1].

ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response.

TNF-α (10-36), human (TFA) is a peptide of human TNF-α.

Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA), is a potent agonist of the melanocortin 2 receptor (MC2).

Nampt-IN-10 TFA (compound 4) is a phosphoribosyltransferase (NAMPT) inhibitor with cellular efficacy against A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), and can be used as a non-antimitotic payload for ADCs.

LH-RH (4-10), a heptapeptide, represents one of the primary degradation products of luteinising-hormone releasing hormone (LHRH), occurring through the pathways of the pituitary and hypothalamus. It is produced in macrophages and type II pneumocytes [1].

Kisspeptin-10, human TFA, is a potent vasoconstrictor and angiogenesis inhibitor that also suppresses tumor metastasis through its interaction with the receptor GPR54. It is crucial for embryonic kidney development and promotes osteoblast differentiation through NFATc4-mediated BMP2 expression via the Kisspeptin-10/GPR54 signaling pathway [1].

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

Super-chelating agent & MRI contrast agent

CysHHC10 TFA is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA) is a minor component of CNS myelin.