api1

API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .

PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM) that retains the active conformation of pXPO5, restoring its ability to transport pre-miRNAs from the nucleus to the cytoplasm, thereby up-regulating anticancer miRNA biogenesis to suppress hepatocellular carcinoma development both in vitro and in vivo. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain, effectively inhibiting Pin1 cis-trans isomerizing activity.

TAPI1 (TAPI) , an ADAM17 TACE inhibitor, inhibits shedding of cytokine receptors.

Api137 is an antimicrobial peptide that disrupts bacterial growth by blocking translation processes, specifically inhibiting protein synthesis by entrapping release factors on the 70S ribosome after hydrolysis of the nascent polypeptide chain [1][2].