gefitinib n-oxide

Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.

Gefitinib N-oxide hydrochloride, an N-oxide derivative of Gefitinib, acts as an EGFR tyrosine kinase inhibitor. Demonstrating an IC50 range of 2-37 nM in NR6wtEGFR cells, it emphasizes its efficacy in inhibiting the enzymatic activity of EGFR [1] [2].

Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.

4-Methylmorpholine N-oxide is often used as a co-oxidant and sacrificial catalyst in oxidation reactions.

Olanzapine N-Oxide is a metabolite of Olanzapine which shows antipsychotic activity.

Rinderine N-oxide, a pyrrolizidine alkaloid, is present in R. graeca [1].

Mirtazapine N-oxide is a metabolite of mirtazapine.1It is formed from mirtazapine by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4 in human liver microsomes.

Nicotinic acid N-oxide (Nicotinic acid 1-oxide) is a nicotinic acid derivative, used to treat hyperlipoidemia.

Sarracine N-oxide is a natural product of Senecio, Asteraceae. The catalog number is TN4952 and the CAS number is 19038-27-8. Sarracine N-oxide can be used as a reference standard.

Netupitant N-oxide D6 is a Netupitant metabolite, is the deuterium labeled Netupitant N-oxide.

Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite.

Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress. 1.Stoltz, R.A., Cyong, J.-C., Shah, A., et al.Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjectsJ. Clin. Pharmacol.44(5)520-531(2004) 2.Vishnu Murthy, M., Srinivas, K., Kumar, R., et al.Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phaseJ. Pharm. Biomed. Anal.56(2)429-435(2011)

Acetylseneciphylline N-oxide is a pyrrolizine alkaloid.

1-Methoxycarbonyl-beta-carboline-N-oxide is a natural product for research related to life sciences. The catalog number is TN6652 and the CAS number is 74690-74-7.

Propiverine N-oxide (hydrochloride) is the major metabolite of propiverine in human plasma or urine.

Echinatine N-oxide is a natural product for research related to life sciences. The catalog number is TN3915 and the CAS number is 20267-93-0.

Abiraterone sulfate N-oxide, a carboxylic acid and major metabolite of Abiraterone, is utilized in prostate cancer research [1] [2].

Canthin-6-one N-oxide has broad spectrum antifungal, leishmanicidal and trypanocidal activities.

Leontalbinine N-oxide is a lupin alkaloid from Sophora flavescen seeds.

Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199), a highly potent, selective, and orally bioavailable inhibitor of Bcl-2, demonstrates a Ki value of less than 0.01 nM [1].

Koumine N-oxide is a natural product from Gelsemium elegans.

Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long-chain inhibitor of 3-ketoyl coenzyme A thiolase (IC50: 75 nM), has anti-oxidant, anti-inflammatory, antinociceptive, and gastroprotective properties.

Heliotrine N-oxide is the pyrrolizidine alkaloid (PA) N-oxide counterpart of Heliotrine. It induces the generation of pyrrolic DNA adducts, potentially initiating PA-induced liver tumors in vivo.

Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (Ki = 15 μM in human liver microsomes).

Galanthamine N-Oxide, an alkaloid extracted from Zephyranthes concolor bulbs, effectively inhibits acetylcholinesterase (AChE) from electric eel with an EC50 of 26.2 μM. It acts as a significant inhibitor of substrate accommodation within the active sites of Torpedo californica AChE (TcAChE), human AChE (hAChE), and human BChE (hBChE) enzymes.

Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole . It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.

Isotetrandrine N-2'-oxide is a natural product for research related to life sciences. The catalog number is TN4335 and the CAS number is 70191-83-2.

Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin . Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.

9-Angeloylretronecine N-oxide is a natural product for research related to life sciences. The catalog number is TN3312 and the CAS number is 27773-86-0.

Lasiocarpine N-oxide is a natural compound found to be higher in many tea bags, herbal drugs and honey by mass spectrometry.

Latifoline N-oxide is a useful organic compound for research related to life sciences and the catalog number is T123821.

Vallesamine N-oxide is a natural product for research related to life sciences. The catalog number is TN5219 and the CAS number is 126594-73-8.

Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. It is utilized in the research of depression and anxiety [1].

Abiraterone N-oxide is a metabolite of Abiraterone . Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity [1] .

Nilotinib N-oxide is a small-molecule tyrosine kinase inhibitor approved for the treatment of imatinib-resistant chronic myelogenous leukemia.

4-Methoxy-2,3,5-trimethylpyride-N-oxide is a useful organic compound for research related to life sciences. The catalog number is T67676 and the CAS number is 86604-80-0.

Europine N-oxide is a useful organic compound for research related to life sciences and the catalog number is T124465.

Riddelline N-oxide is a useful organic compound for research related to life sciences and the catalog number is T124271.

Neratinib dimethylamine N-oxide is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity.

Afatinib N-Oxide is an impurity of Afatinib in oxidative degradation. Afatinib is an irreversible EGFR family inhibitor.

Clozapine N-oxide dihydrochloride is a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs) that crosses the blood-brain barrier.Clozapine N-oxide dihydrochloride induces activation of DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride induces activation of DREADD receptors hM3Dq and hM4Di.

Heliosupine N-oxide is a useful organic compound for research related to life sciences and the catalog number is T125058.

Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.

Piribedil N-oxide, a metabolite of the dopamine receptor agonist piribedil, represents a chemical compound involved in the metabolic processing of its parent compound, piribedil.

Regorafenib-13C-d3 N-Oxide the 13C and deuterated compound of Regorafenib N-Oxide. Regorafenib N-Oxide has a CAS number of 835621-11-9. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).

Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research.

Neratinib pyridine N-oxide is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity.

Crebanine N-oxide is a useful organic compound for research related to life sciences. The catalog number is T126510 and the CAS number is 102719-85-7.

Rizatriptan N-oxide is a potential impurity found in commercial preparations of rizatriptan.1It is a degradation product formed under oxidative conditions.

Loratadine N-oxide is a metabolite of the histamine H1 receptor inverse agonist loratadine.