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immunosuppressive efficacy

" in TargetMol Product Catalog
  • Inhibitor Products
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    TargetMol | Activity
  • PROTAC Products
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CS 2100
T22697913827-99-3
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.
  • $41
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SS47
T745082636072-62-1
SS47, a PROTAC -based HPK1 degrader , exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the?in?vivo?antitumor efficacy of BCMA CAR-T cell research. HPK1, an?immunosuppressive?regulatory kinase, is a promising target for cancer immunotherapies [1] .
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EVT801
T735161412453-70-3
EVT801 is an orally active, selective VEGFR-3 inhibitor (IC 50 = 11 nM) with demonstrated antitumor properties. It effectively suppresses VEGF-C-induced human endothelial cell proliferation and tumor (lymphatic) angiogenesis in mouse models. Moreover, EVT801 reduces tumor hypoxia and the production of immunosuppressive cytokines (CCL4, CCL5) and myeloid-derived suppressor cells (MDSC), enhancing the efficacy of immune checkpoint therapy (ICT). This synergy results in improved ICT response rates and more potent anticancer effects in cancer mouse models.
  • $1,970
8-10 weeks
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