jms 17 2

JMS-17-2 is a potent and selective antagonist of CX3CR1 (IC50: 0.32 nM).

JMS-17-2 hydrochloride, a highly potent and selective CX3CR1 antagonist with an IC 50 value of 0.32 nM, effectively impedes the metastatic seeding and colonization process of breast cancer cells.

6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile is a biologically active compound, which is utilized for research in the fields of chemistry and life sciences.

2-chloro-5-(16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid can be used to synthesize a variety of organic compounds.

Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].

Dynorphin (2-17) (porcine), a Prodynorphin-derived peptide, can alleviate somatic symptoms of Morphine dependence during withdrawal [1].

SARS-CoV-2-IN-17 (Compound 16) is a highly effective inhibitor of the SARS-CoV-2 nucleocapsid protein (NPro), demonstrating potent antiviral activity with an EC50 value of 2.18 μM and binding to NPro with a low Kd value of 7.82 μM, underscoring its potency as a NPro ligand [1].

Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-end

VEGFR-2-IN-17 (Compound 15a) is a highly potent inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) with an IC50 of 67.25 nM and exhibits significant antitumor properties [1].

Myr-Arf1(2–17) is a myristoylated peptide utilized to simulate the localization and function of the Arf1 protein on the cell membrane. This compound is also employed in investigating the desensitization mechanisms of the luteinizing hormone chorionic gonadotropin receptor (LH CGR).

(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate is a useful organic compound for research related to life sciences. The catalog number is T65075 and the CAS number is 17110-51-9.

[3-(tetrahydro-2H-pyran-2-yloxy)androstan-17-yl]methanol is a useful organic compound for research related to life sciences and the catalog number is T131410.

Compound 159, an IL-17 modulator 2, is an orally active modulator of IL-17 that significantly reduces IL-6, IFN-γ, and edema, and can be used in arthritis studies [1].

Bcl-2-IN-17, a Bcl2 inhibitor, is utilized for researching diseases associated with the Bcl anti-apoptotic protein [1].

(2b,3a,5a,16b,17b)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane is a useful organic compound for research related to life sciences. The catalog number is T66654 and the CAS number is 119302-24-8.

17-(iodomethyl)-3-(tetrahydro-2H-pyran-2-yloxy)androstane is a useful organic compound for research related to life sciences and the catalog number is T131409.

Dynorphin (2-17), amide (porcine) is a dynorphin derivative from the opioid peptide class, synthesized from the precursor protein dynorphinogen, and exhibits analgesic properties, playing a pivotal role in regulating pain, addiction, and mood [1].

COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.

ARF1 (2-17) inhibits both ARF-dependent (i.e., PLD) and ARF-independent pathways (i.e., PLC-β). This compound also suppresses GTP-γ-S-stimulated PLD activity, phospholipase C-β (PLC-β), and exocytosis.